Inflammatory markers in a 2-year soy intervention among premenopausal women.
Inflammatory markers in a 2-year soy intervention among premenopausal women.
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DOI：
10.1186/1476-9255-6-9
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发表时间：
2009-04-07
期刊：
影响因子：
--
通讯作者：
Cooney RV
中科院分区：
文献类型：
--
作者：
Maskarinec G;Steude JS;Franke AA;Cooney RV
流行病学证据支持大豆食品在乳腺癌病因学中的作用。由于慢性炎症似乎是致癌的关键因素，我们研究了大豆食品的潜在抗炎作用。最初的2年饮食干预随机选取了220名绝经前妇女，其中183名妇女（干预组90名，对照组93名）被纳入目前的研究；40%的人有亚洲血统。干预组每天食用两份含有50毫克异黄酮（糖苷元等量）的大豆，而对照组则保持常规饮食。分别于第0、3、6、12和24个月采集5份血清样本，采用ELISA法检测白细胞介素(IL)-6、c反应蛋白（CRP）、瘦素和脂联素。为了进行统计分析，采用混合模型纳入重复测量。结果：所有分析物的水平在亚洲妇女低于白种人。超重女性的CRP、IL-6和瘦素水平明显高于正常体重女性，而脂联素水平较低。我们没有观察到大豆食品对这四种标志物的显著影响，但对照组瘦素增加，干预组没有（组时间效应p = 0.20）；这一差异在亚洲女性（p = 0.01）和肥胖女性（p = 0.005）中尤为显著。在这项为期2年的干预中，大豆食品没有改变绝经前妇女血清中CRP、IL-6、瘦素和脂联素的水平，尽管干预组中肥胖或亚洲血统的妇女瘦素水平保持稳定。有必要进一步研究不同的炎症标志物，以阐明大豆对免疫反应的具体影响。
Epidemiologic evidence supports a role of soy foods in breast cancer etiology. Because chronic inflammation appears to be a critical component in carcinogenesis, we examined the potential anti-inflammatory effects of soy foods. The original 2-year dietary intervention randomized 220 premenopausal women of whom 183 women (90 in the intervention group and 93 in the control group) were included in the current investigation; 40% were of Asian ancestry. The intervention group consumed two daily soy servings containing 50 mg of isoflavones (aglycone equivalents), whereas the controls maintained their regular diet. Five serum samples obtained at month 0, 3, 6, 12, and 24 were analyzed for interleukin (IL)-6, C-reactive protein (CRP), leptin, and adiponectin by ELISA. For statistical analysis, mixed models were applied to incorporate the repeated measurements. Results: The levels of all analytes were lower in Asian than Caucasian women. Overweight women had significantly higher levels of CRP, IL-6, and leptin and lower levels of adiponectin than normal weight women. We did not observe a significant effect of soy foods on the four markers, but leptin increased in the control and not in the intervention group (p = 0.20 for group-time effect); this difference was significant for Asian (p = 0.01) and obese women (p = 0.005). During this 2-year intervention, soy foods did not modify serum levels of CRP, IL-6, leptin, and adiponectin in premenopausal women although leptin levels remained stable among women in the intervention group who were obese or of Asian ancestry. Further studies with diverse markers of inflammation are necessary to clarify the specific effect of soy on immune responses.
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DOI：
10.3181/00379727-217-44231
发表时间：
1998-03-01
影响因子：
--
作者：
Franke, AA;Custer, LJ;Shi, CY
通讯作者：
Shi, CY
影响因子：
4.4
作者：
Kelley, DS
通讯作者：
Kelley, DS
DOI：
10.1016/s0002-8223(03)00377-8
发表时间：
2003-07-01
影响因子：
--
作者：
Maskarinec, G;Robbins, C;Murphy, S
通讯作者：
Murphy, S
影响因子：
4.9
作者：
Deurenberg, P;Yap, M;van Staveren, WA
通讯作者：
van Staveren, WA
影响因子：
158.5
作者：
ANDERSON, JW;JOHNSTONE, BM;COOKNEWELL, ME
通讯作者：
COOKNEWELL, ME