What, Me Worry and Ruminate About DSM-5 and RDoC? The Importance of Targeting Negative Self-Referential Processing.
What, Me Worry and Ruminate About DSM-5 and RDoC? The Importance of Targeting Negative Self-Referential Processing.
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DOI：
10.1111/cpsp.12038
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Fresco DM
中科院分区：
文献类型：
--
作者：
Mennin DS;Fresco DM
沉思、担忧和其他形式的负面自我参照加工(NSRP)是每个人都熟悉的，因为反思自我可能是我们最人性的特征。然而，对于很大一部分患者来说，NSRP是由于强烈的情绪性而出现的，会恶化临床表现，并降低治疗反应。情绪性和NSRP的结合可能反映了在我们的试验和临床中未能获得满意治疗反应的复杂和治疗难治性患者的内在表型。一个重要的下一步是通过在已建立的治疗方案内或在迄今的新治疗方案中故意针对NSRP来个人化治疗。用正念冥想丰富治疗是对这种假想的内表型患者进行个性化护理的一种可能途径。
Rumination, worry, and other forms of negative self-referential processing (NSRP) are familiar to everyone, as reflecting on the self is perhaps our most human characteristic. However, for a substantial subgroup of patients, NSRP arises in response to intense emotionality, worsening the clinical presentation, and diminishing the treatment response. The combination of emotionality and NSRP likely reflects an endophenotype of complicated and treatment refractory patients who fail to achieve a satisfactory treatment response in our trials and our clinics. An important next step is to personalize treatments by deliberately targeting NSRPs within established treatment protocols or in as yet novel treatments. Enriching treatments with mindfulness meditation is one possible avenue for personalized care of patients with this hypothesized endophenotype.
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