Vitamin and mineral supplements in pregnancy and the risk of childhood acute lymphoblastic leukaemia: a case-control study.
Vitamin and mineral supplements in pregnancy and the risk of childhood acute lymphoblastic leukaemia: a case-control study.
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DOI：
10.1186/1471-2458-7-136
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发表时间：
2007-07-03
影响因子：
4.5
通讯作者：
Elwood M
中科院分区：
文献类型：
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作者：
Dockerty JD;Herbison P;Skegg DC;Elwood M
来自西澳大利亚州的一项早期病例对照研究报告了孕妇在怀孕期间补充叶酸对儿童急性淋巴细胞白血病（ALL）风险的保护作用。本研究测试了这种关联。在新西兰进行了一项全国病例对照研究。97名ALL儿童和303名对照儿童的母亲被问及怀孕期间服用维生素和矿物质补充剂的情况。报告的妊娠期叶酸摄入量与儿童ALL之间没有关联（校正比值比（OR）1.1，95%置信区间（CI）0.5-2.7）。将我们的结果与来自西澳大利亚的研究和来自魁北克的另一项研究在荟萃分析中结合，得出总结OR为0.9（95% CI 0.8-1.1）。我们自己的研究与澳大利亚的研究规模相似，不支持叶酸对儿童ALL具有保护作用的假设。荟萃分析的结果也是如此。
An earlier case-control study from Western Australia reported a protective effect of maternal folic acid supplementation during pregnancy on the risk of childhood acute lymphoblastic leukaemia (ALL). The present study tested that association. A national case-control study was conducted in New Zealand. The mothers of 97 children with ALL and of 303 controls were asked about vitamin and mineral supplements taken during pregnancy. There was no association between reported folate intake during pregnancy and childhood ALL (adjusted odds ratio (OR) 1.1, 95% confidence interval (CI) 0.5–2.7). Combining our results with the study from Western Australia and another study from Québec in a meta-analysis gave a summary OR of 0.9 (95% CI 0.8–1.1). Our own study, of similar size to the Australian study, does not support the hypothesis of a protective effect of folate on childhood ALL. Neither do the findings of the meta-analysis.
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影响因子：
8.8
作者：
Dockerty, JD;Skegg, DCG;Elwood, JM;Herbison, GP;Becroft, DMO;Lewis, ME
通讯作者：
Lewis, ME
影响因子：
2.3
作者：
Jensen, CD;Block, G;Month, S
通讯作者：
Month, S
影响因子：
2.3
作者：
Shaw, AK;Infante-Rivard, C;Morrison, HI
通讯作者：
Morrison, HI
影响因子：
5
作者：
Kwan, Marilyn L.;Metayer, Catherine;Buffler, Patricia A.
通讯作者：
Buffler, Patricia A.
影响因子：
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作者：
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