Relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from Nunavik.
Relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from Nunavik.
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DOI：
10.1289/ehp.1003296
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发表时间：
2011-08
影响因子：
10.4
通讯作者：
Dewailly É
中科院分区：
文献类型：
--
作者：
Ayotte P;Carrier A;Ouellet N;Boiteau V;Abdous B;Sidi EA;Château-Degat ML;Dewailly É
背景：甲基汞（MeHg）暴露与冠心病（CHD）风险增加有关。对氧磷酶1（PON 1）是一种位于高密度脂蛋白（HDL）部分的酶，可通过代谢与低密度脂蛋白和HDL相关的毒性氧化脂质来预防CHD。甲基汞已被证明在体外抑制PON 1活性，但尚未在人群中研究这种影响。目的：这项研究的目的是确定因纽特人的血液汞水平是否与血浆PON 1活性降低有关，因纽特人通过以海鲜为基础的饮食高度暴露于甲基汞。研究方法：我们测量了896因纽特成年人的血浆PON 1活性，使用荧光底物和血液中的汞和硒浓度的电感耦合等离子体质谱法。在多变量分析中，社会人口统计学、人体测量学、临床、饮食和生活方式变量以及PON 1基因变异（rs705379、rs662、rs 854560）被认为是汞-PON 1关系的可能混杂因素或修饰因素。结果如下：在校正了年龄、高密度脂蛋白胆固醇水平、红细胞膜ω-3脂肪酸含量和PON 1变异体的多元回归模型中，血汞浓度与PON 1活性呈负相关[β系数= -0.063; 95%置信区间（CI）为-0.091至-0.035;血硒浓度与PON 1活性呈正相关（β系数= 0.067; 95% CI，0.045-0.088; p < 0.001）。我们发现血汞水平和PON 1基因型之间没有相互作用。结论：我们的研究结果表明，甲基汞暴露对PON 1活性产生抑制作用，这似乎是抵消硒摄入。
Background: Methylmercury (MeHg) exposure has been linked to an increased risk of coronary heart disease (CHD). Paraoxonase 1 (PON1), an enzyme located in the high-density–lipoprotein (HDL) fraction of blood lipids, may protect against CHD by metabolizing toxic oxidized lipids associated with low-density liproprotein and HDL. MeHg has been shown to inhibit PON1 activity in vitro, but this effect has not been studied in human populations. Objectives: This study was conducted to determine whether blood mercury levels are linked to decreased plasma PON1 activities in Inuit people who are highly exposed to MeHg through their seafood-based diet. Methods: We measured plasma PON1 activity using a fluorogenic substrate and blood concentrations of mercury and selenium by inductively coupled plasma mass spectrometry in 896 Inuit adults. Sociodemographic, anthropometric, clinical, dietary, and lifestyle variables as well as PON1 gene variants (rs705379, rs662, rs854560) were considered as possible confounders or modifiers of the mercury–PON1 relation in multivariate analyses. Results: In a multiple regression model adjusted for age, HDL cholesterol levels, omega-3 fatty acid content of erythrocyte membranes, and PON1 variants, blood mercury concentrations were inversely associated with PON1 activities [β-coefficient = –0.063; 95% confidence interval (CI), –0.091 to –0.035; p < 0.001], whereas blood selenium concentrations were positively associated with PON1 activities (β-coefficient = 0.067; 95% CI, 0.045–0.088; p < 0.001). We found no interaction between blood mercury levels and PON1 genotypes. Conclusions: Our results suggest that MeHg exposure exerts an inhibitory effect on PON1 activity, which seems to be offset by selenium intake.
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影响因子：
5.1
作者：
Gonzalvo, MC;Gil, F;Pla, A
通讯作者：
Pla, A
影响因子：
9.8
作者：
Brophy, VH;Jampsa, RL;Furlong, CE
通讯作者：
Furlong, CE
影响因子：
4.1
作者：
Corcoran, AC;Rabinowitch, IM
通讯作者：
Rabinowitch, IM
影响因子：
5.3
作者：
Jorgensen, Marit Eika;Bjerregaard, Peter;Borch-Johnsen, Knut
通讯作者：
Borch-Johnsen, Knut
影响因子：
10.4
作者：
Li, Wan-Fen;Pan, Mei-Hung;Chuang, Hung-Yi
通讯作者：
Chuang, Hung-Yi