Current Advances in Aptamers for Cancer Diagnosis and Therapy.
Current Advances in Aptamers for Cancer Diagnosis and Therapy.
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DOI：
10.3390/cancers10010009
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发表时间：
2018-01-03
期刊：
影响因子：
5.2
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Hori SI;Herrera A;Rossi JJ;Zhou J
Nucleic acid aptamers are single-stranded oligonucleotides that interact with target molecules with high affinity and specificity in unique three-dimensional structures. Aptamers are generally isolated by a simple selection process called systematic evolution of ligands by exponential enrichment (SELEX) and then can be chemically synthesized and modified. Because of their high affinity and specificity, aptamers are promising agents for biomarker discovery, as well as cancer diagnosis and therapy. In this review, we present recent progress and challenges in aptamer and SELEX technology and highlight some representative applications of aptamers in cancer therapy.
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影响因子：
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作者：
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通讯作者：
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