Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app.
Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app.
复制标题
DOI：
10.1136/bmjnph-2021-000250
复制
发表时间：
2021
影响因子：
--
通讯作者：
Menni C
中科院分区：
文献类型：
--
作者：
Louca P;Murray B;Klaser K;Graham MS;Mazidi M;Leeming ER;Thompson E;Bowyer R;Drew DA;Nguyen LH;Merino J;Gomez M;Mompeo O;Costeira R;Sudre CH;Gibson R;Steves CJ;Wolf J;Franks PW;Ourselin S;Chan AT;Berry SE;Valdes AM;Calder PC;Spector TD;Menni C
膳食补充剂可能会改善SARS-CoV-2感染，尽管缺乏支持这种作用的科学证据。我们调查了定期服用膳食补充剂的COVID-19症状研究应用程序的用户是否不太可能检测出SARS-CoV-2感染阳性。基于app的社区调查。在英国（n=372 720）、美国（n=45 757）和瑞典（n=27 373）的普通人群中，推出了一款应用程序，使用户能够自我报告与SARS-CoV-2感染相关的信息。在截至2020年7月31日的第一波大流行期间，自我报告的定期膳食补充剂使用情况（前3个月持续使用）。2020年7月31日前经病毒RNA逆转录酶PCR检测或血清学检测证实的SARS-CoV-2感染。在372 720名英国参与者（175 652名补充剂使用者和197 068名非补充剂使用者）中，在调整潜在混杂因素后，服用益生菌、omega-3脂肪酸、多种维生素或维生素D的人感染SARS-CoV-2的风险分别降低了14% （95% CI(8%至19%)）、12% （95% CI(8%至16%)）、13% （95% CI(10%至16%)）和9% （95% CI(6%至12%)）。服用维生素C、锌或大蒜补充剂的人没有观察到任何影响。在性别、年龄和身体质量指数（BMI）的分层中，在所有年龄和BMI组的女性中都观察到服用益生菌、omega-3脂肪酸、多种维生素和维生素D的个体的保护关联，但在男性中没有发现。在美国和瑞典的队列中观察到相同的总体关联模式。在女性中，我们观察到益生菌、omega-3脂肪酸、多种维生素或维生素D补充剂的使用与SARS-CoV-2检测呈阳性的风险较低之间存在适度但显著的关联。我们没有发现维生素C、大蒜或锌对男性有明显的益处，也没有发现任何效果。在提出任何治疗建议之前，需要进行随机对照试验来证实这些观察结果。
Dietary supplements may ameliorate SARS-CoV-2 infection, although scientific evidence to support such a role is lacking. We investigated whether users of the COVID-19 Symptom Study app who regularly took dietary supplements were less likely to test positive for SARS-CoV-2 infection. App-based community survey. 445 850 subscribers of an app that was launched to enable self-reported information related to SARS-CoV-2 infection for use in the general population in the UK (n=372 720), the USA (n=45 757) and Sweden (n=27 373). Self-reported regular dietary supplement usage (constant use during previous 3 months) in the first waves of the pandemic up to 31 July 2020. SARS-CoV-2 infection confirmed by viral RNA reverse transcriptase PCR test or serology test before 31 July 2020. In 372 720 UK participants (175 652 supplement users and 197 068 non-users), those taking probiotics, omega-3 fatty acids, multivitamins or vitamin D had a lower risk of SARS-CoV-2 infection by 14% (95% CI (8% to 19%)), 12% (95% CI (8% to 16%)), 13% (95% CI (10% to 16%)) and 9% (95% CI (6% to 12%)), respectively, after adjusting for potential confounders. No effect was observed for those taking vitamin C, zinc or garlic supplements. On stratification by sex, age and body mass index (BMI), the protective associations in individuals taking probiotics, omega-3 fatty acids, multivitamins and vitamin D were observed in females across all ages and BMI groups, but were not seen in men. The same overall pattern of association was observed in both the US and Swedish cohorts. In women, we observed a modest but significant association between use of probiotics, omega-3 fatty acid, multivitamin or vitamin D supplements and lower risk of testing positive for SARS-CoV-2. We found no clear benefits for men nor any effect of vitamin C, garlic or zinc. Randomised controlled trials are required to confirm these observational findings before any therapeutic recommendations can be made.
登录
查看更多内容
影响因子：
7.8
作者：
Giefing-Kröll C;Berger P;Lepperdinger G;Grubeck-Loebenstein B
通讯作者：
Grubeck-Loebenstein B
影响因子：
44.5
作者：
Jolliffe, David A.;Camargo, Carlos A., Jr.;Martineau, Adrian R.
通讯作者：
Martineau, Adrian R.
影响因子：
16.6
作者：
Griffith GJ;Morris TT;Tudball MJ;Herbert A;Mancano G;Pike L;Sharp GC;Sterne J;Palmer TM;Davey Smith G;Tilling K;Zuccolo L;Davies NM;Hemani G
通讯作者：
Hemani G
影响因子：
4.4
作者：
Caccialanza, Riccardo;Laviano, Alessandro;Cereda, Emanuele
通讯作者：
Cereda, Emanuele
DOI：
10.3390/ijerph17165770
发表时间：
2020-08-01
影响因子：
--
作者：
Guzek, Dominika;Skolmowska, Dominika;Glabska, Dominika
通讯作者：
Glabska, Dominika