Mannose-binding lectin and the balance between immune protection and complication.
Mannose-binding lectin and the balance between immune protection and complication.
复制标题
DOI：
10.1586/eri.11.136
复制
发表时间：
2011-12
影响因子：
5.7
通讯作者：
Takahashi K
中科院分区：
文献类型：
--
作者：
Takahashi K
先天免疫系统在进化上是古老的，在生物学上是原始的。从历史上看，它首先被确定为免疫系统的一个元素，提供对病原体的第一线反应，并且越来越多地被认为是其中心管家作用及其在组织稳态中的基本功能，包括凝血和炎症等。甘露糖结合凝集素（MBL）是一种模式识别分子，是先天免疫系统和其他功能之间的关键联系。多项研究已经证明，MBL缺乏增加了对感染的易感性，并且与这种对感染的易感性相关的机制包括减少的调理吞噬杀伤和减少的凝集素补体途径的激活。我们实验室的结果已经证明MBL和MBL相关丝氨酸蛋白酶（MASP）-1/3一起介导凝血因子样活性，包括凝血酶样活性。MBL和/或MASP-1/3缺陷型宿主证明了MBL和MASP-1/3参与损伤后止血的体内证据。金黄色葡萄球菌感染的MBL缺失小鼠发生弥散性血管内凝血，这与血液IL-6水平升高（而不是TNF-α）和全身炎症反应相关。感染的MBL缺失小鼠也会发生肝损伤。这些发现表明MBL缺乏可能表现为弥散性血管内凝血和器官衰竭伴感染。从这些观察开始，这篇综述着重于先天免疫和其他稳态系统的相互作用，其紊乱可能导致感染和其他炎症状态的并发症。
The innate immune system is evolutionarily ancient and biologically primitive. Historically, it was first identified as an element of the immune system that provides the first-line response to pathogens, and increasingly it is recognized for its central housekeeping role and its essential functions in tissue homeostasis, including coagulation and inflammation, among others. A pivotal link between the innate immune system and other functions is mannose-binding lectin (MBL), a pattern recognition molecule. Multiple studies have demonstrated that MBL deficiency increases susceptibility to infection, and the mechanisms associated with this susceptibility to infection include reduced opsonophagocytic killing and reduced activation of the lectin complement pathway. Results from our laboratory have demonstrated that MBL and MBL-associated serine protease (MASP)-1/3 together mediate coagulation factor-like activities, including thrombin-like activity. MBL and/or MASP-1/3-deficient hosts demonstrate in vivo evidence that MBL and MASP-1/3 are involved with hemostasis following injury. Staphylococcus aureus-infected MBL null mice developed disseminated intravascular coagulation, which was associated with elevated blood IL-6 levels (but not TNF-α) and systemic inflammatory responses. Infected MBL null mice also develop liver injury. These findings suggest that MBL deficiency may manifest as disseminated intravascular coagulation and organ failure with infection. Beginning from these observations, this review focuses on the interaction of innate immunity and other homeostatic systems, the derangement of which may lead to complications in infection and other inflammatory states.
登录
查看更多内容
影响因子：
4.9
作者：
Esmon, CT
通讯作者：
Esmon, CT
影响因子：
5.9
作者：
Carrera, Matilde Campos;Moura, Patricia;Sarinho, Emanuel
通讯作者：
Sarinho, Emanuel
影响因子：
2.7
作者：
D'Avignon, Laurie C.;Hogan, Brian K.;Wolf, Steven E.
通讯作者：
Wolf, Steven E.
影响因子：
3.6
作者：
Bulla, R.;De Seta, F.;Tedesco, F.
通讯作者：
Tedesco, F.
影响因子：
8.8
作者：
Bakhtiari, K;Meijers, JCM;Levi, M
通讯作者：
Levi, M