Lipid and Bile Acid Dysmetabolism in Crohn's Disease.
Lipid and Bile Acid Dysmetabolism in Crohn's Disease.
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DOI：
10.1155/2018/7270486
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发表时间：
2018
影响因子：
4.1
通讯作者：
Kobashi G
中科院分区：
文献类型：
--
作者：
Uchiyama K;Kishi H;Komatsu W;Nagao M;Ohhira S;Kobashi G
克罗恩病是全身性自身免疫性疾病之一。它通常影响小肠和结肠，但也可能涉及从口腔到肛门的胃肠道的任何部分。克罗恩病最受影响的区域是小肠的远端部分，其中胆汁酸分子的重吸收效率最高。胆汁酸与脂肪酸一起形成混合胶束，其作为运输工具将脂肪酸递送至肠上皮细胞的顶膜以供吸收。因此，如果回肠末端受损，可能会出现胆汁酸吸收不良，从而可能导致克罗恩病的先天性腹泻。同样，回肠末端的损伤也会引起脂肪酸吸收不良，这可能会影响脂肪酸在克罗恩病中的作用。相比之下，最近的一项研究报告称，在部分克罗恩病患者中，多药耐药蛋白 1 (MDR1) 通过胆汁酸驱动的氧化应激和 MDR1 功能丧失来调节回肠中的效应 T 细胞功能。然而，消耗脂肪酸在克罗恩病中的作用仍有待充分阐明。本综述旨在从综合角度概述克罗恩病研究的最新进展，重点关注疾病部位和行为、脂质饮食和胆汁酸吸收不良之间的联系。
Crohn's disease is one of the systemic autoimmune diseases. It commonly affects the small intestine and colon but may involve any portion of the gastrointestinal tract from the mouth to the anus. The most affected area by Crohn's disease is the distal part of the small intestine, in which the bile acid molecules are most efficiently reabsorbed. Bile acids form mixed micelles together with fatty acids, which function as a transport vehicle to deliver fatty acids to the apical membrane of enterocytes for absorption. Therefore, if the terminal ileum is impaired, bile acid malabsorption may occur, which may cause congenital diarrhoea in Crohn's disease. Similarly, the impairment of the terminal ileum also induces fatty acid malabsorption, which may influence the role of fatty acids in Crohn's disease. In contrast, a recent study reported that multidrug resistance protein 1 (MDR1) regulated effector T-cell function in the ileum from bile acid-driven oxidative stress and MDR1 loss of function in a subset of patients with Crohn's disease. However, the role of consumption of fatty acids in Crohn's disease remains to be fully elucidated. This review is aimed at providing an overview of some recent developments in research of Crohn's disease from comprehensive perspective with a focus on the connection between disease location and behaviour, lipid diets, and bile acid malabsorption.
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影响因子：
8
作者：
Lo, B.;Vester-Andersen, M. K.;Burisch, J.
通讯作者：
Burisch, J.
影响因子：
120.7
作者：
Feagan, Brian G.;Sandborn, William J.;Rutgeerts, Paul
通讯作者：
Rutgeerts, Paul
影响因子：
9.8
作者：
Amre, Devendra K.;D'Souza, Savio;Seidman, Ernest G.
通讯作者：
Seidman, Ernest G.
两个不同的元群落表征了克罗恩病患者的肠道微生物群
影响因子：
9.2
作者：
He Q;Gao Y;Jie Z;Yu X;Laursen JM;Xiao L;Li Y;Li L;Zhang F;Feng Q;Li X;Yu J;Liu C;Lan P;Yan T;Liu X;Xu X;Yang H;Wang J;Madsen L;Brix S;Wang J;Kristiansen K;Jia H
通讯作者：
Jia H
DOI：
10.1001/jama.2013.4466
发表时间：
2013-05-22
期刊：
JAMA
影响因子：
--
作者：
Cheifetz AS
通讯作者：
Cheifetz AS