Suppression of deep brain stimulation artifacts from the electroencephalogram by frequency-domain Hampel filtering.
Suppression of deep brain stimulation artifacts from the electroencephalogram by frequency-domain Hampel filtering.
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DOI：
10.1016/j.clinph.2010.02.156
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Mackinnon CD
中科院分区：
文献类型：
--
作者：
Allen DP;Stegemöller EL;Zadikoff C;Rosenow JM;Mackinnon CD
目前，脑电(EEG)不能用来记录临床有效的DBS期间的皮质活动，这是因为存在大量的刺激伪影，其成分与EEG的有用频谱重叠。提出了一种去除这些伪影的滤波方法，同时保持了基本脑电的频谱和时间保真度。该滤波器基于Hampel识别器，该识别器将伪影视为频域中的异常值，并用内插值替换它们。利用合成的DBS信号和双边单极DBS过程中记录的实际数据对滤波器的性能进行了测试。单频刺激的平均信噪比提高了7.8分贝，双频刺激的平均信噪比提高了13.8分贝。有人工合成伪影的脑电和无人工产物的脑电之间的相关性分析表明，滤波信号中对潜在脑电的失真可以忽略不计(R2>；0.99)。频域Hampel滤波已被证明在用于治疗帕金森氏病的一些常见刺激条件下可以去除单极DBS伪影。频域Hampel滤波的应用将允许在临床有效的DBS期间测量患者的脑电，从而可能增加我们对这一重要治疗干预的作用机制的理解。
Currently, electroencephalography (EEG) cannot be used to record cortical activity during clinically effective DBS due to the presence of large stimulation artifact with components that overlap the useful spectrum of the EEG. A filtering method is presented that removes these artifacts whilst preserving the spectral and temporal fidelity of the underlying EEG. The filter is based on the Hampel identifier that treats artifacts as outliers in the frequency domain and replaces them with interpolated values. Performance of the filter was tested with a synthesized DBS signal and actual data recorded during bilateral monopolar DBS. Mean increases in signal-to-noise ratio of 7.8 dB for single-frequency stimulation and 13.8 dB for dual-frequency stimulation are reported. Correlation analysis between EEG with synthesized artifacts and artifact-free EEG reveals that distortion to the underlying EEG in the filtered signal is negligible (r2 > 0.99). Frequency-domain Hampel filtering has been shown to remove monopolar DBS artifacts under a number of common stimulation conditions used for the treatment of Parkinson’s disease. Application of frequency-domain Hampel filtering will allow the measurement of EEG in patients during clinically effective DBS and thus may increase our understanding of the mechanisms of action of this important therapeutic intervention.
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