The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts, and sesame seeds.
The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts, and sesame seeds.
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DOI：
10.1016/j.jaci.2020.11.004
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Schein CH
中科院分区：
文献类型：
--
作者：
Dreskin SC;Koppelman SJ;Andorf S;Nadeau KC;Kalra A;Braun W;Negi SS;Chen X;Schein CH
对花生、坚果和芝麻过敏是过敏反应的最重要的食物相关原因之一。重要的临床问题包括：为什么在这些食物中存在可变的共同过敏发生率，这是免疫介导的吗？本文总结的临床和免疫学数据表明，基于2S-白蛋白之间的相似性，这些共同过敏的免疫学基础。来自组分分辨诊断的数据突出了IgE与这些过敏原的结合与IgE介导的食物过敏的存在之间的关系。此外，在体外和体内实验提供了强有力的证据表明，2S白蛋白是花生中最重要的过敏原诱导过敏效应反应。虽然2S白蛋白是不同的，但它们具有共同的二硫键连接的核心，具有相似的物理化学性质，这使它们成为解释花生、树坚果和芝麻籽中观察到的大部分共同过敏的主要候选者。腰果和开心果共同过敏的明确频率（64-100%）强调了其2S白蛋白之间的结构相似性如何解释观察到的临床交叉反应性。全面了解花生、坚果和芝麻中2S白蛋白的理化性质将提高我们诊断、治疗和最终预防这些过敏的能力。
Allergies to peanuts, tree nuts, and sesame seeds are among the most important food related causes of anaphylaxis. Important clinical questions include: why is there a variable occurrence of co-allergy among these foods and is this immunologically mediated? Clinical and immunological data summarized here suggest an immunologic basis for these co-allergies based on similarities among the 2S-albumins. Data from component resolved diagnostics have highlighted the relationship between IgE binding to these allergens and the presence of IgE-mediated food allergy. Furthermore, in vitro and in vivo experiments provide strong evidence that the 2S albumins are the most important allergens in peanuts for inducing an allergic effector response. Although the 2S albumins are diverse, they have a common disulfide linked core with similar physicochemical properties that make them prime candidates to explain much of the observed co-allergy among peanuts, tree nuts and sesame seeds. The well-established frequency of cashew and pistachio nut co-allergy (64–100%) highlights how the structural similarities among their 2S albumins may account for observed clinical cross-reactivity. A complete understanding of the physicochemical properties of the 2S albumins in peanuts, tree nuts and sesame seeds will enhance our ability to diagnose, treat and ultimately prevent these allergies.
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影响因子：
14.2
作者：
Albrecht, Melanie;Kuehne, Yvonne;Vieths, Stefan
通讯作者：
Vieths, Stefan
DOI：
10.1016/j.jaci.2010.10.007
发表时间：
2010-12
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
NIAID-Sponsored Expert Panel;Boyce JA;Assa'ad A;Burks AW;Jones SM;Sampson HA;Wood RA;Plaut M;Cooper SF;Fenton MJ;Arshad SH;Bahna SL;Beck LA;Byrd-Bredbenner C;Camargo CA Jr;Eichenfield L;Furuta GT;Hanifin JM;Jones C;Kraft M;Levy BD;Lieberman P;Luccioli S;McCall KM;Schneider LC;Simon RA;Simons FE;Teach SJ;Yawn BP;Schwaninger JM
通讯作者：
Schwaninger JM
影响因子：
3.5
作者：
Du, Xuye;Tang, Heng;Kong, Lingrang
通讯作者：
Kong, Lingrang
影响因子：
12.4
作者：
Beyer, K.;Grabenhenrich, L.;Niggemann, B.
通讯作者：
Niggemann, B.
影响因子：
5.1
作者：
ALTENBACH, SB;KUO, CC;TOWNSEND, J
通讯作者：
TOWNSEND, J