Vitamin E is essential for Purkinje neuron integrity.
Vitamin E is essential for Purkinje neuron integrity.
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DOI：
10.1016/j.neuroscience.2013.12.001
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发表时间：
2014-02-28
期刊：
影响因子：
3.3
通讯作者：
Manor, D.
中科院分区：
文献类型：
--
作者：
Ulatowski, L.;Parker, R.;Warrier, G.;Sultana, R.;Butterfield, D. A.;Manor, D.
Alpha-tocopherol (vitamin E) is an essential dietary antioxidant with important neuroprotective functions. Alpha-tocopherol deficiency manifests primarily in neurological pathologies, notably cerebellar dysfunctions such as spinocerebellar ataxia. To study the roles of α-tocopherol in the cerebellum, we used the Ttpa-/- mice which lack the tocopherol transfer protein (TTP) and are a faithful model of vitamin E deficiency and oxidative stress. When fed vitamin E deficient diet, Ttpa-/- mice had un-detectable levels of α-tocopherol in plasma and several brain regions. Dietary supplementation with α-tocopherol normalized plasma levels of the vitamin, but only modestly increased its levels in the cerebellum and prefrontal cortex, indicating a critical function of brain TTP. Vitamin E deficiency caused an increase in cerebellar oxidative stress evidenced by increased protein nitrosylation, which was prevented by dietary supplementation with the vitamin. Concomitantly, vitamin E deficiency precipitated cellular atrophy and diminished dendritic branching of Purkinje neurons, the predominant output regulator of the cerebellar cortex. The anatomic decline induced by vitamin E deficiency was paralleled by behavioral deficits in motor coordination and cognitive functions that were normalized upon vitamin E supplementation. These observations underscore the essential role of vitamin E and TTP in maintaining CNS function, and support the notion that α-tocopherol supplementation may comprise an effective intervention in oxidative stress-related neurological disorders.
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影响因子：
5.5
作者：
ECCLES, JC;LLINAS, R;SASAKI, K
通讯作者：
SASAKI, K
影响因子：
2.5
作者：
ALTMAN, J
通讯作者：
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影响因子：
11
作者：
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DOI：
10.1196/annals.1331.012
发表时间：
2004-01-01
期刊：
VITAMIN E AND HEALTH
影响因子：
--
作者：
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通讯作者：
Traber, MG
影响因子：
4.4
作者：
GOSSSAMPSON, MA;KRISS, A;MULLER, DPR
通讯作者：
MULLER, DPR