HPV-16, HPV-58, and HPV-33 are the most carcinogenic HPV genotypes in Southwestern China and their viral loads are associated with severity of premalignant lesions in the cervix.
HPV-16, HPV-58, and HPV-33 are the most carcinogenic HPV genotypes in Southwestern China and their viral loads are associated with severity of premalignant lesions in the cervix.
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DOI：
10.1186/s12985-018-1003-x
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发表时间：
2018-05-25
期刊：
影响因子：
4.8
通讯作者：
Sun X
中科院分区：
文献类型：
--
作者：
Long W;Yang Z;Li X;Chen M;Liu J;Zhang Y;Sun X
目前，人乳头瘤病毒58在中国西南部的作用尚不清楚。尽管存在一些争议，但有人认为HPV的病毒载量与上皮内病变的严重程度有关。我们确定了来自川南及邻近地区的7747名患者，他们在2013年至2017年期间被诊断为HPV感染者。分析HR-HPV亚型分布，并用实时定量RT-PCR定量患者的病毒载量。在所有7747例HPV基因筛查患者中，1728例(22.31%)被确认为HR-HPV亚型。在无上皮内病变的患者中(12.41%)，HPV-52、HPV-16和HPV-58是HR-HPV最常见的三种亚型。在宫颈上皮内瘤变II级(42.86%)和III级(59.81%)患者中，HPV-16、HPV-58和HPV-33是最常见的亚型，占浸润性宫颈癌(ICC)的69.34%。因此，HPV-58、HPV-16和HPV-33的病毒载量与宫颈病变的严重程度呈正相关(P <； 分别为0.001、P = 0.016和P = 0.026)。应用受试者工作特征(ROC)曲线分析，获得了预测HPV-16、HPV-58和HPV-33感染病例(CINI、CINIII和ICC)严重上皮内病变的最佳阈值，分别为1、0.93和0.25。在我们的研究中，我们发现HPV-16是中国西南地区最常见的致癌HPV亚型，其次是HPV-58和HPV-33。这些亚型的病毒载量与宫颈癌前病变的严重程度有关。本文的在线版本(10.1186/s12985-0181003-x)包含补充材料，可供授权用户使用。
Currently, the role of human papillomavirus (HPV)-58 in southwestern China has been unexplored. Although there is some controversy, it is proposed that the viral load of HPV correlates with the severity of intraepithelial lesions. We identified 7747 patients from south Sichuan and adjacent regions who were diagnosed with HPV between 2013 and 2017. The HR-HPV subtype distribution was analyzed and the patient’s viral loads were quantified using real-time RT-PCR. Among all 7747 patients screened for HPV genotypes, 1728 patients (22.31%) were identified as having HR-HPV subtypes. In patients without intraepithelial lesions (12.41%), HPV-52, HPV-16, and HPV-58 were the three most prevalent HR-HPV subtypes. Moreover, HPV-16, HPV-58, and HPV-33 were the most prevalent subtypes in patients with cervical intraepithelial neoplasia grade II (CINII) (42.86%) and grade III (CINIII) (59.81%), and accounted for the majority of invasive cervical cancer (ICC) (69.34%). Thus, viral loads of HPV-58, HPV-16, and HPV-33 positively correlated with the severity of cervical lesions (P < 0.001, P = 0.016, P = 0.026, respectively). Using receiver operating characteristic (ROC) curve analysis, the optimum thresholds for predicting severe intraepithelial lesions of cases (CINI, CINIII and ICC) with HPV-16, HPV-58, and HPV-33, respectively, were obtained, which were 1, 0.93, and 0.25, respectively. In our study, we showed that HPV-16 was the most common carcinogenic HPV subtype in southwestern China followed by HPV-58 and HPV-33. Viral loads of these subtypes are associated with the severity of premalignant lesions in the cervix. The online version of this article (10.1186/s12985-018-1003-x) contains supplementary material, which is available to authorized users.
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影响因子：
8.8
作者：
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影响因子：
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作者：
de Martel C;Plummer M;Vignat J;Franceschi S
通讯作者：
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DOI：
10.1093/jnci/94.2.102
发表时间：
2002-01-16
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
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通讯作者：
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通讯作者：
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影响因子：
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作者：
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