Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila.
Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila.
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果蝇膳食金纳米粒子的 Akt 信号相关代谢效应
DOI：
10.1038/srep00563
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发表时间：
2012
影响因子：
4.6
通讯作者：
Song, Haiyun
中科院分区：
文献类型：
--
作者：
Wang, Bin;Chen, Nan;Wei, Yingliang;Li, Jiang;Sun, Li;Wu, Jiarui;Huang, Qing;Liu, Chang;Fan, Chunhai;Song, Haiyun
金纳米颗粒(AuNPs)由于对细胞的存活和增殖作用温和，常被用作药物或生物分子的载体。然而，人们对它们对细胞新陈代谢的影响知之甚少。在这里，我们以果蝇为模型，研究了AuNPs对体内代谢的影响。果蝇和脊椎动物具有相似的基本代谢功能，高度保守的PI3K/Akt/mTOR信号通路在两种生物的能量代谢调节中发挥着核心作用。我们发现，食物中的AuNPs进入了脂肪体，这是果蝇幼虫的关键代谢组织。值得注意的是，摄食AuNP的幼虫显示出不会触发应激反应的血脂水平增加。此外，PI3K/Akt/mTOR信号通路的活性和脂肪酸的合成也在这些幼虫中增加。因此，本研究揭示了AuNPs在影响动物代谢方面的新功能，并提出了其在代谢紊乱治疗中的潜在应用。
Gold nanoparticles (AuNPs) are often used as vehicles to deliver drugs or biomolecules, due to their mild effect on cell survival and proliferation. However, little is known about their effect on cellular metabolism. Here we examine the in vivo effect of AuNPs on metabolism using Drosophila as a model. Drosophila and vertebrates possess similar basic metabolic functions, and a highly conserved PI3K/Akt/mTOR signaling pathway plays a central role in the regulation of energy metabolism in both organisms. We show that dietary AuNPs enter the fat body, a key metabolic tissue in Drosophila larvae. Significantly, larvae fed with AuNP show increased lipid levels without triggering stress responses. In addition, activities of the PI3K/Akt/mTOR signaling pathway and fatty acids synthesis are increased in these larvae. This study thus reveals a novel function of AuNPs in influencing animal metabolism and suggests its potential therapeutic applications for metabolic disorders.
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影响因子：
4
作者：
Huang, Haojie;Tindall, Donald J.
通讯作者：
Tindall, Donald J.
影响因子：
13.3
作者：
Simonsen, Anne;Cumming, Robert C.;Finley, Kim D.
通讯作者：
Finley, Kim D.
用于长范围单倍型高通量基因分型的金纳米颗粒
影响因子：
38.3
作者：
Chen, Peng;Pan, Dun;Shi, Yongyong
通讯作者：
Shi, Yongyong
影响因子：
16.6
作者：
Liu, JW;Lu, Y
通讯作者：
Lu, Y
影响因子：
29
作者：
Porstmann T;Santos CR;Griffiths B;Cully M;Wu M;Leevers S;Griffiths JR;Chung YL;Schulze A
通讯作者：
Schulze A