Slow stabilization of concurrently acquired hippocampal context representations.
Slow stabilization of concurrently acquired hippocampal context representations.
复制标题
同时获得的海马上下文表征的缓慢稳定。
DOI：
10.1002/hipo.22656
复制
发表时间：
2016
期刊：
影响因子：
3.5
通讯作者：
Smith,DavidM
中科院分区：
文献类型：
--
作者：
Law,LMatthew;Bulkin,DavidA;Smith,DavidM
海马神经元表现出空间上的局部放电模式，在种群水平上代表特定的环境或背景。许多研究已经研究了当环境改变时，海马神经元如何从现有的表征切换到新的表征，这一过程被称为重新映射。人们普遍认为，新的陈述会在几分钟内迅速出现，然后保持非常稳定。然而，最近的一些研究表明，海马体的表征可能比之前认为的更加流畅，以前的大多数研究只要求受试者从熟悉的环境切换到新的环境。在本研究中，我们通过将大鼠暴露在ABAB模式下的两个不同的环境环境中，检验了两种不同的海马体表征的同时发展，并记录了每天八次训练的神经元活动。在第一天，海马神经元在最初暴露于每种环境中时，表现出正常的位置场和典型的放电特性。然而，当大鼠在第二个环境中度过15分钟后返回到原始环境时，许多神经元在新的位置(即它们重新映射)被激活，就像大鼠遇到了新的环境一样。到第三天，这些陈述已经稳定下来，并且在同一背景下的访问中高度一致。这些结果表明，当受试者同时编码多个上下文时，海马区的表征可能需要重复经历才能完全稳定。©2016 Wiley期刊，Inc.
Hippocampal neurons exhibit spatially localized firing patterns that, at the population level, represent a particular environment or context. Many studies have examined how hippocampal neurons switch from an existing representation to a new one when the environment is changed, a process referred to as remapping. New representations were commonly thought to emerge rapidly, within a few minutes and then remain remarkably stable thereafter. However, a number of recent studies suggest that hippocampal representations may be more fluid than previously thought and most of the previous studies only required that subjects switch from a familiar environment to a novel one. In the present study, we examined the concurrent development of two distinct hippocampal representations by exposing rats to two distinct environmental contexts in an ABAB pattern and we recorded neuronal activity for eight daily training sessions. Hippocampal neurons exhibited normal place fields with typical firing properties during the initial exposure to each context on the first day. However, when the rats were returned to the original context after having spent 15 min in the second context, many of the neurons fired in new locations (i.e., they remapped) as if the rat had encountered a new environment. By the third day, the representations had stabilized and were highly consistent across visits to the same context. These results suggest that when subjects concurrently encode multiple contexts, hippocampal representations may require repeated experiences to fully stabilize. © 2016 Wiley Periodicals, Inc.
登录
查看更多内容
影响因子：
4.3
作者：
Roudi Y;Treves A
通讯作者：
Treves A
老鼠、网、地图和位置细胞的出现
DOI：
--
发表时间：
1992
期刊：
Psychobiology
影响因子：
--
作者：
A. Treves;O. Miglino;D. Parisi
通讯作者：
D. Parisi
影响因子：
3.5
作者：
Molter, Colin;Yamaguchi, Yoko
通讯作者：
Yamaguchi, Yoko
影响因子：
5.3
作者：
BIENENSTOCK, EL;COOPER, LN;MUNRO, PW
通讯作者：
MUNRO, PW
影响因子：
5.6
作者：
Mehta, MR
通讯作者：
Mehta, MR