Effect of Routine Varicella Immunization on the Epidemiology and Immunogenicity of Varicella and Shingles.
Effect of Routine Varicella Immunization on the Epidemiology and Immunogenicity of Varicella and Shingles.
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DOI：
10.3390/v14030588
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发表时间：
2022-03-12
期刊：
影响因子：
--
通讯作者：
Okuno T
中科院分区：
文献类型：
--
作者：
Otani N;Shima M;Yamamoto T;Okuno T
水痘带状疱疹病毒 (VZV) 会导致水痘作为原发性感染，并在神经节中保持潜伏状态，直至重新激活导致带状疱疹。水痘患者会产生适应性体液免疫和细胞介导的免疫。细胞介导的免疫力受损被认为导致带状疱疹的发生。最近的证据表明，水痘流行病学的变化影响了带状疱疹的流行病学。带状疱疹的发病率在老年人中较高；因此，建议老年人接种带状疱疹疫苗。然而，带状疱疹的发病率预计在年轻人中会上升；因此，年轻人也应考虑接种水痘疫苗。为了确定不同人群是否需要接种疫苗，建立准确评估细胞免疫和体液免疫活性的方法非常重要。
Varicella-zoster virus (VZV) causes varicella as a primary infection and remains latent in the ganglia until it becomes reactivated to cause herpes zoster. Individuals with varicella develop adaptive humoral and cell-mediated immunity. Compromised cell-mediated immunity is thought to contribute to the development of herpes zoster. Recent evidence suggests that changes in the epidemiology of varicella have affected the epidemiology of herpes zoster. The incidence of herpes zoster is higher in older adults; thus, the herpes zoster vaccine is recommended for older adults. However, the incidence of herpes zoster is expected to rise among younger individuals; hence, vaccination with the varicella vaccine should also be considered in younger adults. In order to determine the need for vaccination in different populations, it is important to establish methods to accurately assess the activity of cell-mediated immunity and humoral immunity.
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