Systematic review of incidence and complications of herpes zoster: towards a global perspective.

Systematic review of incidence and complications of herpes zoster: towards a global perspective.
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DOI:
10.1136/bmjopen-2014-004833
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发表时间:
2014-06-10
期刊:
影响因子:
2.9
通讯作者:
Acosta CJ
Acosta CJ
中科院分区:
医学3区
文献类型:
--
作者:
Kawai K;Gebremeskel BG;Acosta CJ

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这项研究的目的是确定带状疱疹(HZ)的发病率,也称为带状疱疹,以及世界各地并发症的风险。我们系统地回顾了研究HZ的发病率,HZ的时间趋势,并发症的风险,包括带状疱疹后神经痛(PHN)和HZ相关的住院和死亡率在一般人群。使用PubMed、EMBASE和WHO图书馆进行文献检索,检索时间截止到2013年12月。我们纳入了在26个国家进行的130项研究。根据使用前瞻性监测、电子病历数据或管理数据和病历审查的研究,北美、欧洲和亚太地区HZ的发生率范围为3 - 5/1000人-年。在过去的几十年里,7个国家报告了HZ发病率的暂时增加,通常发生在水痘疫苗接种计划实施之前。发生PHN的风险从5%到30%以上不等,这取决于研究设计的类型、研究人群的年龄分布和定义。超过30%的PHN患者持续疼痛超过1年。 HZ复发的风险范围为1%至6%,长期随访研究显示风险较高(5-6%)。住院率范围为2 - 25/100 000人-年,老年人群的住院率更高。 HZ是一个重大的全球健康负担,预计随着人口老龄化而增加。未来的研究必须采用严格的方法。
The objective of this study was to characterise the incidence rates of herpes zoster (HZ), also known as shingles, and risk of complications across the world. We systematically reviewed studies examining the incidence rates of HZ, temporal trends of HZ, the risk of complications including postherpetic neuralgia (PHN) and HZ-associated hospitalisation and mortality rates in the general population. The literature search was conducted using PubMed, EMBASE and the WHO library up to December 2013. We included 130 studies conducted in 26 countries. The incidence rate of HZ ranged between 3 and 5/1000 person-years in North America, Europe and Asia-Pacific, based on studies using prospective surveillance, electronic medical record data or administrative data with medical record review. A temporal increase in the incidence of HZ was reported in the past several decades across seven countries, often occurring before the introduction of varicella vaccination programmes. The risk of developing PHN varied from 5% to more than 30%, depending on the type of study design, age distribution of study populations and definition. More than 30% of patients with PHN experienced persistent pain for more than 1 year. The risk of recurrence of HZ ranged from 1% to 6%, with long-term follow-up studies showing higher risk (5–6%). Hospitalisation rates ranged from 2 to 25/100 000 person-years, with higher rates among elderly populations. HZ is a significant global health burden that is expected to increase as the population ages. Future research with rigorous methods is important.
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