The development of the national tuberculosis research priority in Indonesia: A comprehensive mixed-method approach.

The development of the national tuberculosis research priority in Indonesia: A comprehensive mixed-method approach.
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DOI:
10.1371/journal.pone.0281591
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发表时间:
2023
期刊:
影响因子:
3.7
通讯作者:
--
中科院分区:
综合性期刊3区
文献类型:
--
作者:

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印度尼西亚在全球结核病(TB)发病率中排名第二,已制定了2020-2024年结核病预防和控制国家战略,以加速结核病消除计划。研究和创新是支持该计划的关键支柱,需要优先考虑。本研究旨在制定印度尼西亚最新的国家结核病研究优先事项。本研究采用开放式问卷调查、文献调查及德尔菲问卷调查相结合的研究方法。公开调查邀请所有相关的结核病利益攸关方回答(a)结核病规划的主要障碍和(B)支持消除结核病的研究的必要性。已发表文献调查检索了2015年至2020年期间发表在国家和国际期刊上的科学文章,以确定已发表的研究与当前国家结核病控制战略之间的差距。在线调查和文献调查为结核病专家小组在两阶段德尔菲调查中选择前10个优先研究主题提供了信息。我们确定了322篇文章,并分析了1143份开放式调查问卷。通过两个阶段的德尔菲调查,列出了十大研究类别:结核病早期发现;耐药结核病的诊断和治疗;接触者调查;儿童结核病病例的发现和治疗;结核病预防性治疗;政府政策;药物敏感和耐药结核病诊断实验室;治疗依从性;诊断工具开发;社区赋权。这项研究还发现了利益相关者的利益与将研究转化为政策和实践的重要性之间的差距。通过各利益攸关方的参与,确定了结核病研究的优先事项。网上调查、文献调查和德尔菲调查相结合的方法是一种严谨的方法,适合于建立结核病研究优先次序的系统共识。
Ranked second in global tuberculosis (TB) incidence, Indonesia has developed a National Strategy for TB Prevention and Control 2020–2024 to accelerate the TB elimination program. Research and innovation are key pillars to support the program and need to be prioritised. This study aimed to develop updated national TB research priorities in Indonesia. This study was a mixed-methods study consisting of an open survey, a published literature survey, and Delphi survey. The open survey invited all related TB stakeholders to answer (a) the main barriers of the TB program and (b) the need for studies to support TB elimination. The published literature survey retrieved scientific articles published in national and international journals between 2015 and 2020 to identify gaps between published research and the current national strategy for TB control. The online survey and literature survey informed a panel of TB experts in a two-phase Delphi Survey to select the top 10 priority research topics. We identified 322 articles and analysed 1143 open survey responses. Through two-phases Delphi surveys, top ten research categories were listed: early TB detection; diagnosis and treatment of DR-TB; contact investigation; case detection and treatment of child TB; TB preventive therapy; government policy; laboratory for drug-sensitive- and drug-resistant-TB diagnosis; treatment adherence; diagnostic tool development; and community empowerment. This study also found the gap between stakeholders’ interests and the importance of translating research into policy and practice. TB research priorities have been identified through the involvement of various stakeholders. The combination of an online survey, a published literature survey, and a Delphi survey was a rigorous methodology and was fit to build a systematic consensus about the priority of TB research.
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