Do parkinsonian patients have trouble telling lies? The neurobiological basis of deceptive behaviour.
Do parkinsonian patients have trouble telling lies? The neurobiological basis of deceptive behaviour.
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DOI：
10.1093/brain/awp052
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Mori E
中科院分区：
文献类型：
--
作者：
Abe N;Fujii T;Hirayama K;Takeda A;Hosokai Y;Ishioka T;Nishio Y;Suzuki K;Itoyama Y;Takahashi S;Fukuda H;Mori E
帕金森病是一种常见的神经退行性疾病，具有运动症状和认知缺陷，例如执行功能障碍。过去 100 年来，越来越多的文献表明，帕金森病患者具有勤奋、严肃和僵化等典型的人格特征。他们也被描述为“诚实”，表明他们有不欺骗他人的倾向。然而，这些性格特征实际上可能与受疾病影响的特定大脑区域的功能障碍有关。在本研究中，我们表明帕金森病患者确实是“诚实的”，这种性格特征可能源于前额叶皮层的功能障碍。通过一项新颖的认知任务，我们证实帕金森病患者 (n = 32) 相对于健康对照组 (n = 20) 难以做出欺骗性反应。此外，使用静息态 18F-氟脱氧葡萄糖 PET，我们发现这种困难与前额叶代谢减退显着相关。我们的研究结果首次证明帕金森病患者表面上的诚实具有神经生物学基础，并且它们为人类欺骗行为至关重要的大脑机制提供了直接的神经心理学证据。
Parkinson's disease is a common neurodegenerative disorder with both motor symptoms and cognitive deficits such as executive dysfunction. Over the past 100 years, a growing body of literature has suggested that patients with Parkinson's disease have characteristic personality traits such as industriousness, seriousness and inflexibility. They have also been described as ‘honest’, indicating that they have a tendency not to deceive others. However, these personality traits may actually be associated with dysfunction of specific brain regions affected by the disease. In the present study, we show that patients with Parkinson's disease are indeed ‘honest’, and that this personality trait might be derived from dysfunction of the prefrontal cortex. Using a novel cognitive task, we confirmed that patients with Parkinson's disease (n = 32) had difficulty making deceptive responses relative to healthy controls (n = 20). Also, using resting-state 18F-fluorodeoxyglucose PET, we showed that this difficulty was significantly correlated with prefrontal hypometabolism. Our results are the first to demonstrate that the ostensible honesty found in patients with Parkinson's disease has a neurobiological basis, and they provide direct neuropsychological evidence of the brain mechanisms crucial for human deceptive behaviour.
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