Childhood cognitive ability accounts for associations between cognitive ability and brain cortical thickness in old age.
Childhood cognitive ability accounts for associations between cognitive ability and brain cortical thickness in old age.
复制标题
DOI：
10.1038/mp.2013.64
复制
发表时间：
2014-05
影响因子：
11
通讯作者：
Deary, I. J.
中科院分区：
文献类型：
--
作者：
Karama, S.;Bastin, M. E.;Murray, C.;Royle, N. A.;Penke, L.;Munoz Maniega, S.;Gow, A. J.;Corley, J.;Hernandez, Mdelc Valdes;Lewis, J. D.;Rousseau, M-E;Lepage, C.;Fonov, V.;Collins, D. L.;Booth, T.;Rioux, P.;Sherif, T.;Adalat, R.;Starr, J. M.;Evans, A. C.;Wardlaw, J. M.;Deary, I. J.
大脑皮层组织体积和老年认知功能之间的关联经常被解释为表明皮层组织的保存是成功认知老化的基础。然而，这种关联也可能部分反映了认知能力和皮质组织之间的终身关联。我们分析了来自1936年洛锡安出生队列的588名受试者的数据，这些受试者在11岁和70岁时都有来自相同认知测试的智商（IQ）评分，以及在大约73岁时获得的高分辨率脑磁共振成像数据。使用自动化流水线在每个受试者的皮质上的81 924个采样点处估计皮质厚度。多元回归被用来评估皮质厚度与11岁和70岁时智商测量值之间的关联。70岁时的智商与73岁时测量的皮质厚度之间的关联中，儿童期智商占了三分之二以上。这警告说，不要基于对衰老过程和任何相关疾病的假设和排他性参考，对老年认知能力和皮层组织之间的关联进行因果解释。如果没有早期认知能力的测量，我们很容易得出结论，老年时皮质厚度的保持是成功认知老化的基础，相反，这是一个终身的联系。话虽如此，结果不应被解释为意味着所有关于衰老的研究都需要直接测量儿童智商，而是表明先前认知功能的代理测量可能是有用的。
Associations between brain cortical tissue volume and cognitive function in old age are frequently interpreted as suggesting that preservation of cortical tissue is the foundation of successful cognitive aging. However, this association could also, in part, reflect a lifelong association between cognitive ability and cortical tissue. We analyzed data on 588 subjects from the Lothian Birth Cohort 1936 who had intelligence quotient (IQ) scores from the same cognitive test available at both 11 and 70 years of age as well as high-resolution brain magnetic resonance imaging data obtained at approximately 73 years of age. Cortical thickness was estimated at 81 924 sampling points across the cortex for each subject using an automated pipeline. Multiple regression was used to assess associations between cortical thickness and the IQ measures at 11 and 70 years. Childhood IQ accounted for more than two-third of the association between IQ at 70 years and cortical thickness measured at age 73 years. This warns against ascribing a causal interpretation to the association between cognitive ability and cortical tissue in old age based on assumptions about, and exclusive reference to, the aging process and any associated disease. Without early-life measures of cognitive ability, it would have been tempting to conclude that preservation of cortical thickness in old age is a foundation for successful cognitive aging when, instead, it is a lifelong association. This being said, results should not be construed as meaning that all studies on aging require direct measures of childhood IQ, but as suggesting that proxy measures of prior cognitive function can be useful to take into consideration.
登录
查看更多内容
影响因子：
5.7
作者：
Karama, Sherif;Colom, Roberto;Johnson, Wendy;Deary, Ian J.;Haier, Richard;Waber, Deborah P.;Lepage, Claude;Ganjavi, Hooman;Jung, Rex;Evans, Alan C.
通讯作者：
Evans, Alan C.
影响因子：
4.1
作者：
Deary IJ;Gow AJ;Taylor MD;Corley J;Brett C;Wilson V;Campbell H;Whalley LJ;Visscher PM;Porteous DJ;Starr JM
通讯作者：
Starr JM
影响因子：
64.8
作者：
Deary, Ian J.;Yang, Jian;Visscher, Peter M.
通讯作者：
Visscher, Peter M.
DOI：
10.1017/s1355617702860131
发表时间：
2002-09-01
影响因子：
2.6
作者：
Bright, P;Jaldow, E;Kopelman, MD
通讯作者：
Kopelman, MD
影响因子：
9.9
作者：
McGurn, B;Starr, JM;Deary, IJ
通讯作者：
Deary, IJ