Transneuronal Degeneration in the Visual Pathway of Rats following Acute Retinal Ischemia/Reperfusion.
Transneuronal Degeneration in the Visual Pathway of Rats following Acute Retinal Ischemia/Reperfusion.
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急性视网膜缺血/再灌注后大鼠视觉通路的跨神经元变性
DOI：
10.1155/2021/2629150
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Wen D
中科院分区：
文献类型：
--
作者：
Fu Y;Hu T;Zhang Q;Meng S;Lu Y;Xiang A;Yin Y;Li Y;Song J;Wen D
视觉功能的维持不仅需要神经元的正常结构和功能，而且依赖于视觉通路中突触的有效信号传播。突触在神经元损伤的早期阶段出现可塑性改变，影响信号传递，导致跨神经元变性。本研究通过建立大鼠急性视网膜缺血/再灌注（RI/R）模型，观察视网膜损伤后内、外丛状层（IPL）和外膝状体背侧核（dLGN）神经元索马体和突触的形态学变化。我们发现RI/R后视觉通路的跨神经元变性具体表现为视网膜神经元索马胞体水肿和线粒体增生，LGN中轴突脱髓鞘和异型蛋白簇。同时，小的未成熟突触形成，突触内突触前和突触后成分之间存在不同步变化。提示RI/R损伤后存在跨神经元变性，这可能是损伤解除后视功能进行性恶化的重要原因之一。
The maintenance of visual function not only requires the normal structure and function of neurons but also depends on the effective signal propagation of synapses in visual pathways. Synapses emerge alterations of plasticity in the early stages of neuronal damage and affect signal transmission, which leads to transneuronal degeneration. In the present study, rat model of acute retinal ischemia/reperfusion (RI/R) was established to observe the morphological changes of neuronal soma and synapses in the inner plexiform layer (IPL), outer plexiform layer (OPL), and dorsal lateral geniculate nucleus (dLGN) after retinal injury. We found transneuronal degeneration in the visual pathways following RI/R concretely presented as edema and mitochondrial hyperplasia of neuronal soma in retina, demyelination, and heterotypic protein clusters of axons in LGN. Meanwhile, small immature synapses formed, and there are asynchronous changes between pre- and postsynaptic components in synapses. This evidence demonstrated that transneuronal degeneration exists in RI/R injury, which may be one of the key reasons for the progressive deterioration of visual function after the injury is removed.
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