Genetic polymorphisms in NQO1 and SOD2: interactions with smoking, schistosoma infection, and bladder cancer risk in Egypt.
Genetic polymorphisms in NQO1 and SOD2: interactions with smoking, schistosoma infection, and bladder cancer risk in Egypt.
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DOI：
10.1016/j.urolonc.2013.06.016
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发表时间：
2014-01
期刊：
影响因子：
--
通讯作者：
Loffredo CA
中科院分区：
文献类型：
--
作者：
Goerlitz D;Amr S;Dash C;Saleh DA;El Daly M;Abdel-Hamid M;El Kafrawy S;Hifnawy T;Ezzat S;Abdel-Aziz MA;Khaled H;Zheng YL;Mikhail N;Loffredo CA
膀胱癌是埃及人中最常见的男性癌症，对埃及人来说，吸烟和血吸虫感染是主要的危险因素。我们假设，NAD(P)H：苯醌氧化还原酶1(NQO1)和超氧化物歧化酶2(SOD2)的功能多态性可以影响个体对这些致癌物质暴露的易感性，从而影响膀胱癌的风险。我们评估了埃及902例患者和804名人群对照人群中NQO1和SOD2基因功能多态与吸烟和SH感染之间潜在的交互作用对膀胱癌风险的影响。我们使用非条件Logistic回归估计优势比(OR)和可信区间(CI)95%。SOD2基因TT基因携带者(OR[CI 95%]=4.41[1.86-10.42])与CC基因携带者(OR[CI 95%]=2.26[0.97-6.74])相比，吸烟和吸烟与癌症风险的相关性更强。相反，后者与SH感染相关的风险(OR[CI 95%]=3.59[2.21-5.84])高于前者(OR[CI 95%]=1.86[1.33-2.60])。NQO1基因的多态性表现出类似的模式，但程度要小得多。同时携带NQO1和SOD2 CC基因的个体在SH感染后患膀胱癌的几率最高(OR[CI 95%]=4.41[2.32~8.38])。我们的研究结果表明，NQO1和SOD2的基因多态性通过调节吸烟和SH感染等已知致病因素的影响，在膀胱癌的病因中发挥重要作用。
Bladder cancer is the most prevalent form of cancer in men among Egyptians, for whom tobacco smoke exposure and Schistosoma haematobium (SH) infection are the major risk factors. We hypothesized that functional polymorphisms in NAD(P)H:quinone oxidoreductase 1 (NQO1) and superoxide dismutase 2 (SOD2), modulators of the effects of reactive oxidative species, can influence an individual's susceptibility to these carcinogenic exposures and hence the risk of bladder cancer. We assessed the effects of potential interactions between functional polymorphisms in the NQO1 and SOD2 genes and exposure to smoking and SH infection on bladder cancer risk among 902 cases and 804 population-based controls in Egypt. We used unconditional logistic regression to estimate the odds ratios (OR) and confidence intervals (CI) 95%. Water pipe and cigarette smoking were more strongly associated with cancer risk among individuals with the TT genotype for SOD2 (OR [CI 95%] = 4.41 [1.86–10.42]) as compared with those with the CC genotype (OR [CI 95%] = 2.26 [0.97–6.74]). Conversely, the risk associated with SH infection was higher among the latter (OR [CI 95%] = 3.59 [2.21–5.84]) than among the former (OR [CI 95%] = 1.86 [1.33–2.60]). Polymorphisms in NQO1 genotype showed a similar pattern, but to a much lesser extent. The highest odds for having bladder cancer following SH infection were observed among individuals with the CC genotypes for both NQO1 and SOD2 (OR [CI 95%] = 4.41 [2.32–8.38]). Our findings suggest that genetic polymorphisms in NQO1 and SOD2 play important roles in the etiology of bladder cancer by modulating the effects of known contributing factors such as smoking and SH infection.
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影响因子：
2.6
作者：
Sutton, A;Imbert, A;Degoul, F
通讯作者：
Degoul, F
影响因子：
6.4
作者：
Hung, RJ;Boffetta, P;Porru, S
通讯作者：
Porru, S
影响因子：
4.9
作者：
Wolpert BJ;Amr S;Ezzat S;Saleh D;Gouda I;Loay I;Hifnawy T;Mikhail NN;Abdel-Hamid M;Zhan M;Zheng YL;Squibb K;Abdel-Aziz MA;Zaghloul M;Khaled H;Loffredo CA
通讯作者：
Loffredo CA
DOI：
10.1158/1055-9965.epi-11-0589
发表时间：
2012-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Zheng YL;Amr S;Saleh DA;Dash C;Ezzat S;Mikhail NN;Gouda I;Loay I;Hifnawy T;Abdel-Hamid M;Khaled H;Wolpert B;Abdel-Aziz MA;Loffredo CA
通讯作者：
Loffredo CA
DOI：
10.1073/pnas.91.18.8413
发表时间：
1994-08-30
影响因子：
11.1
作者：
JOSEPH, P;JAISWAL, AK
通讯作者：
JAISWAL, AK