Estrogen exposure and bladder cancer risk in Egyptian women.
Estrogen exposure and bladder cancer risk in Egyptian women.
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DOI：
10.1016/j.maturitas.2010.07.014
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发表时间：
2010-12
期刊：
影响因子：
4.9
通讯作者：
Loffredo CA
中科院分区：
文献类型：
--
作者：
Wolpert BJ;Amr S;Ezzat S;Saleh D;Gouda I;Loay I;Hifnawy T;Mikhail NN;Abdel-Hamid M;Zhan M;Zheng YL;Squibb K;Abdel-Aziz MA;Zaghloul M;Khaled H;Loffredo CA
研究埃及妇女生殖史与膀胱癌之间的关系。我们使用的问卷数据来自埃及一项正在进行的多中心病例对照研究。对照组的年龄和居住区域相匹配。本分析集中于确诊的尿路上皮（UC）和鳞状细胞（SCC）膀胱癌的女性病例。我们招募了779名女性（540名对照，239例病例，其中98.0%不吸烟）。绝经年龄较年轻（<45岁）和首次怀孕年龄较大（18岁）是膀胱癌风险增加的显著相关因素，即使在多变量logistic模型中调整了血吸虫病史和其他协变量后也是如此；校正后的优势比和95%置信区间分别为1.98（1.41,2.77）和6.26（3.46,11.34）。另一方面，多胎妊娠或使用口服避孕药与膀胱癌的发病率降低有关。单独分析时，UC和SCC也存在类似的关联；然而，与SCC的关联程度低于UC。我们的数据表明，早期雌激素暴露或相对缺乏，在埃及妇女膀胱癌的发展中起作用。
To examine associations between reproductive history and urinary bladder cancer in Egyptian women. We used questionnaire data from an ongoing, multicenter case-control study in Egypt. Controls were matched on age and residence area. This analysis focused on female cases with confirmed urothelial (UC) and squamous cell (SCC) carcinoma of the bladder. We recruited 779 women (540 controls, 239 cases; >98.0% nonsmokers). Younger age at menopause (<45 y) and older age at first pregnancy (>18 y) were factors significantly associated with increased risk of bladder cancer, even after adjusting for schistosomiasis history and other covariates in the multivariable logistic model; adjusted odds ratio and 95% confidence intervals were 1.98 (1.41, 2.77) and 6.26 (3.46, 11.34), respectively. On the other hand, multiple pregnancies or use of oral contraceptives were associated with decreased odds of having bladder cancer. Similar associations were observed with UC and SCC when analyzed separately; however, the magnitude of association with SCC was lower than with UC. Our data suggest that early estrogen exposure, or the relative lack of it, plays a role in urinary bladder carcinoma development among Egyptian women.
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影响因子：
8.8
作者：
Bedwani, R;Renganathan, E;El Kwhsky, F;Braga, C;Abu Seif, H H;Abul Azm, T;Zaki, A;Franceschi, S;Boffetta, P;La Vecchia, C
通讯作者：
La Vecchia, C
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
DOI：
10.4269/ajtmh.2000.63.133
发表时间：
2000-09-01
影响因子：
3.3
作者：
Hodder, SL;Mahmoud, AAF;King, CH
通讯作者：
King, CH
影响因子：
2.3
作者：
CANTOR, KP;LYNCH, CF;JOHNSON, D
通讯作者：
JOHNSON, D
影响因子：
6.4
作者：
Hemelt, Marjolein;Yamamoto, Hidekazu;Zeegers, Maurice P. A.
通讯作者：
Zeegers, Maurice P. A.