Plasma hydrogen sulfide: A biomarker of Alzheimer's disease and related dementias.
Plasma hydrogen sulfide: A biomarker of Alzheimer's disease and related dementias.
复制标题
DOI：
10.1002/alz.12305
复制
发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Kevil CG
中科院分区：
文献类型：
--
作者：
Disbrow E;Stokes KY;Ledbetter C;Patterson J;Kelley R;Pardue S;Reekes T;Larmeu L;Batra V;Yuan S;Cvek U;Trutschl M;Kilgore P;Alexander JS;Kevil CG
虽然心脏病仍然是死亡的常见原因，但脑血管疾病也会随着年龄的增长而增加，并且与阿尔茨海默病和相关痴呆症 (ADRD) 有关。我们描述了硫化氢（H2S），一种对血管稳态很重要的信号分子，作为心血管疾病的生物标志物。我们假设血浆 H2S 及其代谢物也与 ADRD 的血管和认知功能障碍有关。我们使用分析生化方法测量血浆 H2S 代谢物，并使用 MRI 来评估 ADRD 微血管疾病指标。与对照组相比，ADRD 中总 H2S 和特定代谢物的水平有所增加。认知和微血管疾病指数与 H2S 水平相关。血浆总硫化物是 ADRD 的最强指标，并部分驱动认知功能障碍和白质病变体积（微血管疾病的指标）之间的关系。我们的研究结果表明，H2S 在痴呆症中失调，为诊断和干预提供了潜在的生物标志物。 ADRD 中硫化物失调的方案。在 ADRD 中，血浆中硫化物积累的增加可能反映了血管室中产生的 H2S 代谢物形成的增加。已知几种硫化物会损害血脑屏障，导致持续的兴奋性毒性应激，并随后导致 ADRD 中出现的脑微血管结构和认知功能的破坏性变化。
While heart disease remains a common cause of mortality, cerebrovascular disease also increases with age, and has been implicated in Alzheimer's disease and related dementias (ADRD). We have described hydrogen sulfide (H2S), a signaling molecule important in vascular homeostasis, as a biomarker of cardiovascular disease. We hypothesize that plasma H2S and its metabolites also relate to vascular and cognitive dysfunction in ADRD. We used analytical biochemical methods to measure plasma H2S metabolites and MRI to evaluate indicators of microvascular disease in ADRD. Levels of total H2S and specific metabolites were increased in ADRD versus controls. Cognition and microvascular disease indices were correlated with H2S levels. Total plasma sulfide was the strongest indicator of ADRD, and partially drove the relationship between cognitive dysfunction and white matter lesion volume, an indicator of microvascular disease. Our findings show that H2S is dysregulated in dementia, providing a potential biomarker for diagnosis and intervention. Scheme for sulfide dysregulation in ADRD. In ADRD, increased accumulation of sulfides, measured in plasma, may reflect increased formation of H2S metabolites produced in the vascular compartment. Several sulfide species are known to impair blood brain barrier leading to persistent excitotoxic stress and subsequent destructive changes in brain microvascular structure and cognitive function seen in ADRD.
登录
查看更多内容
DOI：
10.1002/alz.12305
发表时间：
2021-08
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Disbrow E;Stokes KY;Ledbetter C;Patterson J;Kelley R;Pardue S;Reekes T;Larmeu L;Batra V;Yuan S;Cvek U;Trutschl M;Kilgore P;Alexander JS;Kevil CG
通讯作者：
Kevil CG
影响因子：
4.8
作者：
Kautzky, Alexander;Seiger, Rene;Lanzenberger, Rupert
通讯作者：
Lanzenberger, Rupert
影响因子：
2.7
作者：
Giuliani, Daniela;Ottani, Alessandra;Guarini, Salvatore
通讯作者：
Guarini, Salvatore
DOI：
10.1016/j.jalz.2018.09.008
发表时间：
2019-03
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Clark LR;Koscik RL;Allison SL;Berman SE;Norton D;Carlsson CM;Betthauser TJ;Bendlin BB;Christian BT;Chin NA;Asthana S;Johnson SC
通讯作者：
Johnson SC
影响因子：
48
作者：
Barnes, Deborah E.;Yaffe, Kristine
通讯作者：
Yaffe, Kristine