Spinal cord GABA receptors modulate the exercise pressor reflex in decerebrate rats.
Spinal cord GABA receptors modulate the exercise pressor reflex in decerebrate rats.
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脊髓 GABA 受体调节去大脑大鼠的运动升压反射。
DOI：
10.1152/ajpregu.00140.2013
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Zucker,IrvingH
中科院分区：
文献类型：
--
作者：
Wang,Han-Jun;Wang,Wei;Patel,KaushikP;Rozanski,GeorgeJ;Zucker,IrvingH
收缩激活的骨骼肌传入脊髓背角释放的神经递质和神经调节剂启动运动加压反射(EPR)的中枢成分。γ-氨基丁酸是哺乳动物中枢神经系统内的一种主要抑制性神经递质，它是否参与了背角水平的肾上腺皮质激素受体的调制尚不清楚。我们在同侧L4/L5背角局部微量注射GABA(A)拮抗剂荷包牡丹碱或GABA(B)拮抗剂CGp 52432，以观察GABA受体阻断剂对刺激L4/L5腹根外周端静止性收缩、被动牵拉或后肢动脉注射辣椒素(0.1μg/0.2ml)引起的升压反应的影响。在L4/5背角内微量注射荷包牡丹碱(1 mM，100nL)或CGP 52432(10 mM，100nL)均可显著增加升压和心脏加速器对所有刺激的反应。在L5背角内微量注射荷包牡丹碱或CGp 52432均可显著增强直接向该脊髓节段微量注射1-谷氨酸(10 mM，100nL)引起的升压反应和心脏加速器反应。微量注射广谱谷氨酸受体拮抗剂犬尿酸(10 mM/100nL)可消除两种GABA受体拮抗剂对EPR的抑制作用。这些结果表明：1)GABA在背角水平对EPR具有紧张性抑制作用；2)在背角水平存在谷氨酸和GABA能传入的相互作用，有助于脊髓对EPR的控制。
Neurotransmitters and neuromodulators released by contraction-activated skeletal muscle afferents into the dorsal horn of the spinal cord initiate the central component of the exercise pressor reflex (EPR). Whether γ-aminobutyric acid (GABA), a major inhibitory neurotransmitter within the mammalian central nervous system, is involved in the modulation of the EPR at the level of dorsal horn remains to be determined. We performed local microinjection of either the GABA(A) antagonist bicuculline or the GABA(B) antagonist CGP 52432 into the ipisilateral L4/L5 dorsal horns to investigate the effect of GABA receptor blockade on the pressor response to either static contraction induced by stimulation of the peripheral end of L4/L5 ventral roots, passive stretch, or hindlimb arterial injection of capsaicin (0.1 μg/0.2 ml) in decerebrate rats. Microinjection of either bicuculline (1 mM, 100 nl) or CGP 52432 (10 mM, 100 nl) into the L4/5 dorsal horns significantly increased the pressor and cardioaccelerator responses to all stimuli. Microinjection of either bicuculline or CGP 52432 into the L5 dorsal horn significantly increased the pressor and cardioaccelerator responses to direct microinjection ofl-glutatmate (10 mM, 100 nl) into this spinal segment. The disinhibitory effect of both GABA receptor antagonists on the EPR was abolished by microinjection of the broad-spectrum glutamate receptor antagonist kynurenate (10 mM/100 nl). These data suggest that1) GABA exerts a tonic inhibition of the EPR at the level of dorsal horn; and2) that an interaction between glutamatergic and GABAergic inputs exist at the level of dorsal horn, contributing to spinal control of the EPR.
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