Plasma NOV/CCN3 levels are closely associated with obesity in patients with metabolic disorders.
Plasma NOV/CCN3 levels are closely associated with obesity in patients with metabolic disorders.
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DOI：
10.1371/journal.pone.0066788
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Guérin M
中科院分区：
文献类型：
--
作者：
Pakradouni J;Le Goff W;Calmel C;Antoine B;Villard E;Frisdal E;Abifadel M;Tordjman J;Poitou C;Bonnefont-Rousselot D;Bittar R;Bruckert E;Clément K;Fève B;Martinerie C;Guérin M
有证据表明，多功能CCN家族的创始人NOV/CCN 3是参与心脏发育、血管稳态和炎症的循环分子。没有关于血浆NOV/CCN 3水平与人类心血管风险因素之间关系的数据。本研究调查了血浆NOV水平与人类心血管危险因素之间的可能关系。在来自594名具有高脂血症史和/或具有降脂治疗和/或体重指数（BMI）>30 kg/m2的成年人的血浆中测量NOV水平。测量NOV血浆水平与各种参数之间的相关性，包括BMI、脂肪量和血浆甘油三酯、胆固醇、葡萄糖和C反应蛋白。还在来自肥胖患者和啮齿动物的脂肪组织中以及在脂肪细胞和巨噬细胞的原代培养物中评价NOV表达。在完全多变量校正后，我们检测到血浆NOV与BMI（r = 0.36 p<0.0001）和脂肪质量（r = 0.33 p<0.0005）之间的强正相关。 五分之一的人认为，这种关系似乎是线性的。NOV水平也与C反应蛋白呈正相关，但与总胆固醇、LDL-C或血糖无关。在Roux-en-Y减肥手术诱导的体重急剧减轻的患者中，手术后3个月和6个月循环NOV水平分别下降了28%（p<0.02）和48%（p<0.0001）。在来自肥胖患者的脂肪组织和人原代培养物中，在脂肪细胞和巨噬细胞中检测到NOV蛋白。在喂食高脂肪饮食的小鼠中，与喂食标准饮食的对照相比，NOV血浆水平及其在脂肪组织中的表达也显著增加。我们的研究结果强烈表明，在肥胖的人类和小鼠中，血浆NOV水平与脂肪组织中NOV的表达呈正相关，并支持NOV对肥胖相关炎症的可能贡献。
Evidence points to a founder of the multifunctional CCN family, NOV/CCN3, as a circulating molecule involved in cardiac development, vascular homeostasis and inflammation. No data are available on the relationship between plasma NOV/CCN3 levels and cardiovascular risk factors in humans. This study investigated the possible relationship between plasma NOV levels and cardiovascular risk factors in humans. NOV levels were measured in the plasma from 594 adults with a hyperlipidemia history and/or with lipid-lowering therapy and/or a body mass index (BMI) >30 kg/m2. Correlations were measured between NOV plasma levels and various parameters, including BMI, fat mass, and plasma triglycerides, cholesterol, glucose, and C-reactive protein. NOV expression was also evaluated in adipose tissue from obese patients and rodents and in primary cultures of adipocytes and macrophages. After full multivariate adjustment, we detected a strong positive correlation between plasma NOV and BMI (r = 0.36 p<0.0001) and fat mass (r = 0.33 p<0.0005). According to quintiles, this relationship appeared to be linear. NOV levels were also positively correlated with C-reactive protein but not with total cholesterol, LDL-C or blood glucose. In patients with drastic weight loss induced by Roux-en-Y bariatric surgery, circulating NOV levels decreased by 28% (p<0.02) and 48% (p<0.0001) after 3 and 6 months, respectively, following surgery. In adipose tissue from obese patients, and in human primary cultures NOV protein was detected in adipocytes and macrophages. In mice fed a high fat diet NOV plasma levels and its expression in adipose tissue were also significantly increased compared to controls fed a standard diet. Our results strongly suggest that in obese humans and mice plasma NOV levels positively correlated with NOV expression in adipose tissue, and support a possible contribution of NOV to obesity-related inflammation.
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影响因子：
8
作者：
Fukunaga-Kalabis, M.;Martinez, G.;Herlyn, M.
通讯作者：
Herlyn, M.
影响因子：
37.8
作者：
Inoue, S;Egashira, K;Takeshita, A
通讯作者：
Takeshita, A
影响因子：
11.1
作者：
Hellström, L;Wahrenberg, H;Arner, P
通讯作者：
Arner, P
影响因子：
5.8
作者：
Bruun, JM;Lihn, AS;Richelsen, B
通讯作者：
Richelsen, B
DOI：
10.1097/01.mco.0000172571.41149.52
发表时间：
2005-07-01
影响因子：
3.1
作者：
Bouloumié, A;Curat, CA;Busse, R
通讯作者：
Busse, R