Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis.
Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis.
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DOI：
10.1038/sj.bjc.6602201
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发表时间：
2004-11-01
影响因子：
8.8
通讯作者：
Satomi, S
中科院分区：
文献类型：
--
作者：
Chiba, T;Ohtani, H;Mizoi, T;Naito, Y;Sato, E;Nagura, H;Ohuchi, A;Ohuchi, K;Shiiba, K;Kurokawa, Y;Satomi, S
T细胞浸润到人类癌组织中可以是宿主对癌细胞的免疫应答的表现。本研究采用371例连续取样的人结直肠癌标本，探讨上皮内CD8+ T细胞的临床病理学意义。通过单因素分析，我们注意到上皮内CD8+ T细胞的生存曲线仅在术后1至2年才开始分离。多变量分析显示，该因素的有益效果仅在较长（超过2年）的随访期后才变得显著，但在较短（不到2年）的随访期后则不显著。此外，存活超过5年的患者的上皮内CD8+ T细胞数量显著高于治愈性手术后死于癌症的患者或接受非治愈性手术的患者。患者在根治性手术后很长时间的癌症特异性死亡被认为是由其他器官或原发部位附近的微转移瘤的生长引起的。因此，上皮内CD8+ T细胞的作用可能是通过抑制微转移而不是抑制原发性肿瘤的生长来介导的。总之，我们的数据支持一个假设的存在对癌细胞的微转移的全身免疫监视。
T-cell infiltration into human cancer tissues can be a manifestation of host immune responses to cancer cells. The present study was undertaken to explore the clinicopathological significance of intraepithelial CD8+ T cells using 371 consecutively sampled human colorectal carcinomas. By univariate analysis, we noted that the survival curves by intraepithelial CD8+ T cells became separated only after 1 to 2 years postoperation. Multivariate analyses revealed that the beneficial effect of this factor becomes significant only after a longer (more than 2 year), but not after a shorter (less than 2 year) follow-up period. Furthermore, the number of intraepithelial CD8+ T cells was significantly higher in patients alive for more than 5 years than in patients who either died of cancer after a curative operation or patients who underwent a noncurative operation. Patients' cancer-specific death long after a curative operation is thought to be caused by the growth of micrometastases in other organs or near the primary sites. The effects of intraepithelial CD8+ T cells, therefore, may be mediated by suppression of micrometastasis, rather than suppression of growth in the primary tumour. In conclusion, our data support a hypothesis on the presence of systemic immunosurveillance against micrometastasis of cancer cells.
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DOI：
10.1084/jem.194.7.953
发表时间：
2001-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Weninger W;Crowley MA;Manjunath N;von Andrian UH
通讯作者：
von Andrian UH
影响因子：
64.8
作者：
Rosenberg, SA
通讯作者：
Rosenberg, SA
影响因子：
5
作者：
Menon, AG;Janssen, CM;Kuppen, PJK
通讯作者：
Kuppen, PJK
影响因子：
6
作者：
Dolcetti, R;Viel, A;Boiocchi, M
通讯作者：
Boiocchi, M
影响因子：
24.5
作者：
Michael-Robinson, JM;Biemer-Hüttmann, AE;Radford-Smith, GL
通讯作者：
Radford-Smith, GL