Activation of RhoA, Smad2, c-Src, PKC-βII/δ and JNK in atopic dermatitis.

Activation of RhoA, Smad2, c-Src, PKC-βII/δ and JNK in atopic dermatitis.
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DOI:
10.1111/ajd.12801
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发表时间:
2018-11
期刊:
The Australasian journal of dermatology
影响因子:
--
通讯作者:
Tan W
Tan W
中科院分区:
其他
文献类型:
--
作者:
Lu J;Yin R;Fu Z;Lee VM;Nelson JS;Tan W

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Atopic dermatitis (AD) is a multifactorial skin disease characterized by chronic and relapsing inflammations, but the pathogenesis is incompletely understood. We found that the expression of TGFbR1 and the activation of SMAD2, RhoA, JNK, PKC-bII/d and c-Src were upregulated in the infiltrated inflammatory cells, fibroblasts and vasculatures in the dermis and epidermis. In addition, increases in the expression of TGFβR1 and phosphorylation levels of JNK and c-Src were positively correlated with the inflammatory progression of AD severity.
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