Activation of RhoA, Smad2, c-Src, PKC-βII/δ and JNK in atopic dermatitis.
Activation of RhoA, Smad2, c-Src, PKC-βII/δ and JNK in atopic dermatitis.
复制标题
DOI:
10.1111/ajd.12801
复制
发表时间:
2018-11
期刊:
影响因子:
--
通讯作者:
Tan W
中科院分区:
文献类型:
--
作者:
Lu J;Yin R;Fu Z;Lee VM;Nelson JS;Tan W
Atopic dermatitis (AD) is a multifactorial skin disease characterized by chronic and relapsing inflammations, but the pathogenesis is incompletely understood. We found that the expression of TGFbR1 and the activation of SMAD2, RhoA, JNK, PKC-bII/d and c-Src were upregulated in the infiltrated inflammatory cells, fibroblasts and vasculatures in the dermis and epidermis. In addition, increases in the expression of TGFβR1 and phosphorylation levels of JNK and c-Src were positively correlated with the inflammatory progression of AD severity.
登录
查看更多内容
影响因子:
2.4
作者:
Malik, Kunal;Heitmiller, Kerry D.;Czarnowicki, Tali
通讯作者:
Czarnowicki, Tali
影响因子:
5.2
作者:
Kim, Hyung-Sik;Yun, Jun-Won;Kang, Kyung-Sun
通讯作者:
Kang, Kyung-Sun
影响因子:
6.1
作者:
Jeong, CW;Ahn, KS;Yang, JM
通讯作者:
Yang, JM
影响因子:
13.8
作者:
Eichenfield, Lawrence F.;Tom, Wynnis L.;Sidbury, Robert
通讯作者:
Sidbury, Robert
影响因子:
9.2
作者:
Han G;Li F;Singh TP;Wolf P;Wang XJ
通讯作者:
Wang XJ