miRGen: a database for the study of animal microRNA genomic organization and function.
miRGen: a database for the study of animal microRNA genomic organization and function.
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DOI：
10.1093/nar/gkl904
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发表时间：
2007-01
影响因子：
14.9
通讯作者：
Hatzigeorgiou AG
中科院分区：
文献类型：
--
作者：
Megraw M;Sethupathy P;Corda B;Hatzigeorgiou AG
miRGen是（i）动物miRNA和基因组注释集之间的位置关系和（ii）根据广泛使用的靶标预测程序的组合的动物miRNA靶标的集成数据库。该数据库的一个主要目标是研究miRNA基因组结构和miRNA功能之间的关系。这是通过三个集成和用户友好的界面。Genomics界面允许用户探索miRNA的全基因组集合相对于UCSC基因组浏览器注释集（例如已知基因、Refseq基因、Genscan预测基因、CpG岛和假基因）的位置。这些miRNA通过Targets接口连接到来自TarBase的实验支持的靶基因，以及来自几种广泛使用的哺乳动物靶预测程序的优化交叉和联合的计算预测的靶基因。最后，集群界面提供了在任何给定的miRNA间距离的预测的miRNA集群，并提供了每个集群内的miRNA靶点的特定功能信息。miRGen的所有这些独特功能旨在促进对miRNA基因组组织，共转录和靶向的研究。miRGen可以在免费访问。
miRGen is an integrated database of (i) positional relationships between animal miRNAs and genomic annotation sets and (ii) animal miRNA targets according to combinations of widely used target prediction programs. A major goal of the database is the study of the relationship between miRNA genomic organization and miRNA function. This is made possible by three integrated and user friendly interfaces. The Genomics interface allows the user to explore where whole-genome collections of miRNAs are located with respect to UCSC genome browser annotation sets such as Known Genes, Refseq Genes, Genscan predicted genes, CpG islands and pseudogenes. These miRNAs are connected through the Targets interface to their experimentally supported target genes from TarBase, as well as computationally predicted target genes from optimized intersections and unions of several widely used mammalian target prediction programs. Finally, the Clusters interface provides predicted miRNA clusters at any given inter-miRNA distance and provides specific functional information on the targets of miRNAs within each cluster. All of these unique features of miRGen are designed to facilitate investigations into miRNA genomic organization, co-transcription and targeting. miRGen can be freely accessed at .
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影响因子：
56.9
作者：
Lagos-Quintana, M;Rauhut, R;Tuschl, T
通讯作者：
Tuschl, T
miRNAMAP：哺乳动物基因组中microRNA基因及其靶基因的基因组图。
影响因子：
14.9
作者：
Hsu, Paul W. C.;Huang, Hsien-Da;Hsu, Sheng-Da;Lin, Li-Zen;Tsou, Ann-Ping;Tseng, Ching-Ping;Stadler, Peter F.;Washietl, Stefan;Hofacker, Ivo L.
通讯作者：
Hofacker, Ivo L.
影响因子：
4.5
作者：
Cai, XZ;Hagedorn, CH;Cullen, BR
通讯作者：
Cullen, BR
影响因子：
10.5
作者：
Mourelatos, Z;Dostie, J;Dreyfuss, G
通讯作者：
Dreyfuss, G
影响因子：
64.5
作者：
Lewis, BP;Shih, IH;Burge, CB
通讯作者：
Burge, CB