Sugar-Sweetened Beverage, Diet Soda, and Nonalcoholic Fatty Liver Disease Over 6 Years: The Framingham Heart Study.
Sugar-Sweetened Beverage, Diet Soda, and Nonalcoholic Fatty Liver Disease Over 6 Years: The Framingham Heart Study.
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DOI：
10.1016/j.cgh.2021.11.001
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发表时间：
2022-11
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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非酒精性脂肪性肝病（NAFLD）与横断面研究中的含糖饮料（SSB）消费相关。在一项前瞻性队列研究中，我们研究了饮料消费（SSB和无糖苏打水）与非酒精性脂肪肝事件和FHS中肝脏脂肪变化的关系。我们对参与计算机断层扫描子研究的FHS第三代和后代队列的参与者进行了一项前瞻性观察性研究。参与者根据他们的平均SSB或无糖汽水消费量进行分类，这些消费量来自基线和随访食物频率问卷：非消费者（0-<1/月），偶尔消费者（1/月-<1/周）和频繁消费者（≥1/周-≥1/天）。通过计算机断层扫描测量肝脏脂肪衰减来量化肝脏脂肪。主要因变量是NAFLD事件;其次，我们研究了肝脏脂肪的变化。队列包括691名后代（平均年龄，62.8 ± 8.2岁; 57.7%为女性）和945名第三代参与者（平均年龄，48.4 ± 6.3岁; 46.6%为女性）。在后代队列中，SSB消耗量与NAFLD事件之间存在剂量-反应关系。多变量分析后，与非消费者相比，经常SSB消费者发生NAFLD的几率增加了2.53倍（95%置信区间，1.36-4.7）。对于后代队列参与者，与非消费者相比，偶尔和频繁消费SSB的肝脏脂肪增加更不利。较高的平均SSB摄入量与6年随访期间肝脏脂肪增加和NAFLD事件发生率增加相关，尤其是在老年队列中，而在年轻的第三代队列中未观察到一致的相关性。
Nonalcoholic fatty liver disease (NAFLD) is associated with sugar-sweetened beverage (SSB) consumption in cross-sectional studies. In a prospective cohort, we examined the association of beverage consumption (SSB and diet soda) with incident NAFLD and changes in hepatic fat in the Framingham Heart Study (FHS). We conducted a prospective observational study of participants from the FHS Third Generation and Offspring cohorts who participated in computed tomography sub-studies. Participants were classified according to their average SSB or diet soda consumption, which was derived from baseline and follow-up food frequency questionnaires: non-consumers (0-<1/month), occasional consumers (1/month-<1/week), and frequent consumers (≥1/week-≥1/day). Hepatic fat was quantified by the liver fat attenuation measurements on computed tomography scan. The primary dependent variable was incident NAFLD; secondarily, we investigated change in liver fat. The cohorts included 691 Offspring (mean age, 62.8 ± 8.2 years; 57.7% women) and 945 Third Generation participants (mean age, 48.4 ± 6.3 years; 46.6% women). In the Offspring cohort, there was a dose-response relationship with SSB consumption and incident NAFLD. Frequent SSB consumers had 2.53 times increased odds of incident NAFLD compared with non-consumers (95% confidence interval, 1.36-4.7) after multivariable analysis. For Offspring cohort participants, occasional and frequent consumers of SSB had a more adverse increase in liver fat compared with non-consumers. Higher average SSB intake is associated with increase in liver fat over 6 years of follow-up and increased odds of incident NAFLD especially among the older cohort, whereas no consistent association was observed for the younger Third Generation cohort.
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