Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study.
Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study.
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DOI：
10.1002/hep.23593
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发表时间：
2010-06
期刊：
影响因子：
13.5
通讯作者：
Fox, Caroline S.
中科院分区：
文献类型：
--
作者：
Speliotes, Elizabeth K.;Massaro, Joseph M.;Hoffmann, Udo;Vasan, Ramachandran S.;Meigs, James B.;Sahani, Dushyant V.;Hirschhorn, Joel N.;O'Donnell, Christopher J.;Fox, Caroline S.
肥胖与代谢后遗症的发生并不一致。身体脂肪分布的特定模式，特别是脂肪肝，可能会优先使高危个体易患疾病。在这里，我们的特点是在一个大的社区为基础的样本与内脏脂肪和不尊重肝脏脂肪的代谢相关性。通过腹部多探测器计算机断层扫描测量了来自社区心脏研究（FHS）的2589名个体的脂肪肝。采用逻辑回归和线性回归确定脂肪肝与心脏代谢危险因素的相关性，调整协变量，调整和不调整其他脂肪库（体重指数[BMI]，腰围[WC]和内脏脂肪组织[VAT]）。脂肪肝的患病率为17%。与没有脂肪肝的参与者相比，患有脂肪肝的个体有更高的糖尿病校正比值比（OR）（DM; OR 2.98; 95%置信区间[CI]，2.12-4.21），代谢综合征（MetS; OR，5.22; 95% CI，4.15-6.57），高血压（HTN; OR 2.73; 95% CI，2.16-3.44），空腹血糖受损（IFG; OR 2.95; 95% CI，2.32-3.75），胰岛素抵抗（IR; OR，6.16; 95% CI，4.90 - 7.76），甘油三酯（TG）以及收缩压和舒张压升高（SBP，DBP）和较低的高密度脂蛋白（HDL）和脂联素水平（所有p<0.001）。在校正其他脂肪库后，脂肪肝仍然与DM、HTN、IFG、MetS、HDL、TG和脂联素水平相关（所有p<0.001），而与SBP和DBP的相关性减弱（p >0.05）。脂肪肝是一种普遍的疾病，其特征是不依赖于VAT和其他肥胖指标的代谢障碍和血脂异常。这项工作开始剖析脂肪库和代谢疾病之间的具体联系。
Obesity is not uniformly associated with the development of metabolic sequelae. Specific patterns of body fat distribution, in particular fatty liver, may preferentially predispose at-risk individuals to disease. Here we characterize the metabolic correlates of fat in the liver in a large community-based sample with and without respect to visceral fat. Fatty liver was measured by multi-detector computed tomography of the abdomen in 2589 individuals from the community-based Framingham Heart Study (FHS). Logistic and linear regression were used to determine the associations of fatty liver with cardio-metabolic risk factors adjusted for covariates with and without adjustment for other fat depots (body mass index [BMI], waist circumference [WC], and visceral adipose tissue [VAT]). The prevalence of fatty liver was 17%. Compared to participants without fatty liver, individuals with fatty liver had a higher adjusted odds ratio (OR) of diabetes (DM; OR 2.98; 95% confidence interval [CI], 2.12–4.21), metabolic syndrome (MetS; OR, 5.22; 95% CI, 4.15–6.57), hypertension (HTN; OR 2.73; 95% CI, 2.16–3.44), impaired fasting glucose (IFG; OR 2.95; 95% CI, 2.32–3.75), insulin resistance (IR; OR, 6.16; 95% CI, 4.90 – 7.76), higher triglycerides (TG) and systolic and diastolic blood pressure (SBP, DBP) and lower high density lipoprotein (HDL) and adiponectin levels (p<0.001 for all). After adjustment for other fat depots, fatty liver remained associated with DM, HTN, IFG, MetS, HDL, TG and adiponectin levels (all p<.001), whereas associations with SBP and DBP were attenuated (p >0.05). Fatty liver is a prevalent condition and is characterized by dysglycemia and dyslipidemia independent of VAT and other obesity measures. This work begins to dissect the specific links between fat depots and metabolic disease.
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影响因子：
16.2
作者：
Jain SH;Massaro JM;Hoffmann U;Rosito GA;Vasan RS;Raji A;O'Donnell CJ;Meigs JB;Fox CS
通讯作者：
Fox CS
影响因子：
120.7
作者：
Flegal, KM;Carroll, MD;Johnson, CL
通讯作者：
Johnson, CL
影响因子：
2.9
作者：
Chen, Chien-Hua;Huang, Min-Ho;Yueh, Sen-Kou
通讯作者：
Yueh, Sen-Kou
DOI：
10.1111/j.1440-1746.2005.04058.x
发表时间：
2005-12-01
影响因子：
4.1
作者：
Fan, JG;Zhu, JN;Chen, SY
通讯作者：
Chen, SY
影响因子：
13.5
作者：
Browning, JD;Szczepaniak, LS;Hobbs, HH
通讯作者：
Hobbs, HH