The genetic architecture of resistance to virus infection in Drosophila.
The genetic architecture of resistance to virus infection in Drosophila.
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DOI：
10.1111/mec.13769
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发表时间：
2016-10
影响因子：
4.9
通讯作者：
Jiggins FM
中科院分区：
文献类型：
--
作者：
Cogni R;Cao C;Day JP;Bridson C;Jiggins FM
在自然种群中，感染易感性的变异有很大的遗传成分，有人认为病原体的选择可能导致它具有比许多其他数量性状更简单的遗传结构。这一点很重要，因为宿主-病原体共同进化的模型通常假设抗性由少数基因控制。利用黑腹果蝇多亲高级杂交，我们研究了对两种天然存在的病毒，西格玛病毒和DCV（果蝇C病毒）的抗性的遗传结构。我们发现对这两种病毒的抗性存在广泛的遗传变异。对于DCV抗性，这种变异主要由两个主要效应位点引起。西格玛病毒抗性涉及更多的基因-我们绘制了五个位点，这些加在一起解释了不到一半的遗传变异。尽管如此，其中一些对抵抗产生了很大的影响。协同进化模型通常假设控制抗性的多态性之间存在强烈的上位性相互作用，但我们只能检测到一个改变我们绘制的主要效应位点的效应的位点。大多数的基因座，我们映射可能是在一个中间的频率在自然群体。总的来说，我们的结果与通常影响感染性疾病易感性的主效应基因一致，DCV抗性是一种接近孟德尔的性状。 另见Magalheses和Sucena的《透视》
Variation in susceptibility to infection has a substantial genetic component in natural populations, and it has been argued that selection by pathogens may result in it having a simpler genetic architecture than many other quantitative traits. This is important as models of host–pathogen co‐evolution typically assume resistance is controlled by a small number of genes. Using the Drosophila melanogaster multiparent advanced intercross, we investigated the genetic architecture of resistance to two naturally occurring viruses, the sigma virus and DCV (Drosophila C virus). We found extensive genetic variation in resistance to both viruses. For DCV resistance, this variation is largely caused by two major‐effect loci. Sigma virus resistance involves more genes – we mapped five loci, and together these explained less than half the genetic variance. Nonetheless, several of these had a large effect on resistance. Models of co‐evolution typically assume strong epistatic interactions between polymorphisms controlling resistance, but we were only able to detect one locus that altered the effect of the main effect loci we had mapped. Most of the loci we mapped were probably at an intermediate frequency in natural populations. Overall, our results are consistent with major‐effect genes commonly affecting susceptibility to infectious diseases, with DCV resistance being a near‐Mendelian trait. see also the Perspective by Magalhães and Sucena
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影响因子：
3.5
作者：
Do R;Kathiresan S;Abecasis GR
通讯作者：
Abecasis GR
影响因子：
56.9
作者：
Buckler, Edward S.;Holland, James B.;McMullen, Michael D.
通讯作者：
McMullen, Michael D.
果蝇抗病毒抗性突变的年龄和演变。
DOI：
10.1098/rspb.2007.0611
发表时间：
2007-08-22
影响因子：
4.7
作者：
Bangham, Jenny;Obbard, Darren J.;Kim, Kang-Wook;Haddrill, Penelope R.;Jiggins, Francis M.
通讯作者：
Jiggins, Francis M.
影响因子：
9.8
作者：
Félix MA;Ashe A;Piffaretti J;Wu G;Nuez I;Bélicard T;Jiang Y;Zhao G;Franz CJ;Goldstein LD;Sanroman M;Miska EA;Wang D
通讯作者：
Wang D
影响因子：
3.4
作者：
Johnson, KN;Christian, PD
通讯作者：
Christian, PD