Anesthesia and developing brain: What have we learned from recent studies.
Anesthesia and developing brain: What have we learned from recent studies.
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麻醉和大脑发育：我们从最近的研究中学到了什么
DOI：
10.3389/fnmol.2022.1017578
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发表时间：
2022
影响因子：
4.8
通讯作者：
Jiang, Hong
中科院分区：
文献类型：
--
作者：
Niu, Yixuan;Yan, Jia;Jiang, Hong
关键词：
麻醉在外科手术中是不可避免的。然而，全身麻醉药是否对未成熟的大脑具有神经毒性仍然不确定。麻醉引起的神经发育障碍一直是一个严重的健康问题和关注的话题。本文综述了近年来在未成熟脑保护方面的临床和临床前研究进展，以期为未成熟脑保护提供有益的建议和潜在的治疗靶点。一方面，临床研究人员继续讨论单次和多次暴露于麻醉对发育中的大脑的影响。另一方面，临床前研究者致力于探索全身麻醉对未成熟脑的神经毒性作用机制，并寻求新的解决方案。啮齿动物模型一直用于临床前研究，但目前仍不清楚在啮齿动物模型中观察到的机制是否具有临床意义。与这些模型相比，非人灵长类动物（NHP）在遗传上与人类更相似。然而，很少有研究机构在这一领域能够负担得起使用NHP模型在他们的研究。解决这两个问题的一种方法是通过结合单细胞测序技术来筛选NHP中的差异基因表达，并在啮齿动物中进行体内验证。麻醉诱导的神经毒性机制仍需进一步阐明。
Anesthesia is unavoidable in surgical procedures. However, whether the general anesthetics are neurotoxic to immature brains remains undefined. Neurodevelopmental impairment induced by anesthesia has been a critical health issue and topic of concern. This review summarizes recent progress made in clinical and preclinical studies to provide useful suggestions and potential therapeutic targets for the protection of the immature brain. On the one hand, clinical researchers continue the debate about the effect of single and multiple exposures to anesthesia on developing brains. On the other hand, preclinical researchers focus on exploring the mechanisms of neurotoxic effects of general anesthesia on immature brains and seeking novel solutions. Rodent models have always been used in preclinical studies, but it is still unclear whether the mechanisms observed in rodent models have clinical relevance. Compared with these models, non-human primates (NHPs) are more genetically similar to humans. However, few research institutions in this area can afford to use NHP models in their studies. One way to address both problems is by combining single-cell sequencing technologies to screen differential gene expression in NHPs and perform in vivo validation in rodents. The mechanism of anesthesia-induced neurotoxicity still requires further elucidation in primates.
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DOI：
10.1016/s0140-6736(15)00608-x
发表时间：
2016-01-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Davidson AJ;Disma N;de Graaff JC;Withington DE;Dorris L;Bell G;Stargatt R;Bellinger DC;Schuster T;Arnup SJ;Hardy P;Hunt RW;Takagi MJ;Giribaldi G;Hartmann PL;Salvo I;Morton NS;von Ungern Sternberg BS;Locatelli BG;Wilton N;Lynn A;Thomas JJ;Polaner D;Bagshaw O;Szmuk P;Absalom AR;Frawley G;Berde C;Ormond GD;Marmor J;McCann ME;GAS consortium
通讯作者：
GAS consortium
影响因子：
9.8
作者：
Alvarado, M. C.;Murphy, K. L.;Baxter, M. G.
通讯作者：
Baxter, M. G.
七氟烷引起的神经炎症的机制。
影响因子：
4.8
作者：
Huang X;Ying J;Yang D;Fang P;Wang X;Zhou B;Zhang L;Fang Y;Yu W;Liu X;Zhen Q;Hua F
通讯作者：
Hua F
LncRNA Riken 通过调节 MicroRNA-101a/MKP-1/JNK 通路减轻七氟烷诱导的神经炎症
影响因子：
3.7
作者：
Hou, Qi;Li, Shuai;Zheng, Hui
通讯作者：
Zheng, Hui
影响因子：
9.8
作者：
Jevtovic-Todorovic, V.;Absalom, A. R.;Hemmings, H. C., Jr.
通讯作者：
Hemmings, H. C., Jr.