The role of neuropeptides in adverse myocardial remodeling and heart failure.
The role of neuropeptides in adverse myocardial remodeling and heart failure.
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DOI：
10.1007/s00018-017-2452-x
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Levick SP
中科院分区：
文献类型：
--
作者：
Widiapradja A;Chunduri P;Levick SP
除了交感神经和副交感神经系统的传统神经递质外，心脏还含有大量的神经肽。这些神经肽不仅调节神经递质的作用，而且对心脏功能也有独立的影响。虽然在大多数情况下，这些神经肽的生理作用已经明确，但人们对它们对心脏病理学的贡献却不太了解。一些神经肽具有心脏保护作用，一些神经肽促进不良心脏重塑和心力衰竭，而另一些神经肽的功能尚不清楚。有些具有心脏保护作用和不良作用，具体取决于具体的心脏病理学和该病理学的进展。在这篇综述中，我们简要描述了几种神经肽对正常心脏生理学的作用，然后更详细地描述它们在不良心脏重塑和心力衰竭中的作用。我们的目标是更多地关注神经肽对心力衰竭发病机制的贡献，并将其视为潜在的治疗靶点。
In addition to traditional neurotransmitters of the sympathetic and parasympathetic nervous systems, the heart also contains numerous neuropeptides. These neuropeptides not only modulate the effects of neurotransmitters, but also have independent effects on cardiac function. While in most cases the physiological actions of these neuropeptides are well defined, what is less appreciated are their contributions to cardiac pathology. Some neuropeptides are cardioprotective, some promote adverse cardiac remodeling and heart failure, and for others their functions are unclear. Some have both cardioprotective and adverse effects depending on the specific cardiac pathology and progression of that pathology. In this review, we briefly describe the actions of several neuropeptides on normal cardiac physiology, before describing in more detail their role in adverse cardiac remodeling and heart failure. It is our goal to bring more focus towards understanding the contribution of neuropeptides to the pathogenesis of heart failure, and to consider them as potential therapeutic targets.
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