Hypothermic temperature effects on organ survival and restoration.
Hypothermic temperature effects on organ survival and restoration.
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DOI：
10.1038/srep09563
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发表时间：
2015-04-22
影响因子：
4.6
通讯作者：
Tsuji T
中科院分区：
文献类型：
--
作者：
Ishikawa J;Oshima M;Iwasaki F;Suzuki R;Park J;Nakao K;Matsuzawa-Adachi Y;Mizutsuki T;Kobayashi A;Abe Y;Kobayashi E;Tezuka K;Tsuji T
三维多细胞生物通过血液循环输送氧气和营养物质，调节体温进行细胞内酶促反应，维持生命支持的生物功能。低温储存供体器官移植是治疗功能障碍器官的基本方法。然而，这种方法有一个严重的问题，即供体器官只能在短期储存期间保持健康状态。在本研究中，我们开发了一种基于生物代谢的新型肝脏灌注培养系统，该系统可以维持生理功能，包括白蛋白合成、胆汁分泌和尿素生成。这个系统也允许严重缺血的肝脏复活。该研究为基于生物代谢的体外器官灌注系统的发展取得了重大进展。它不仅可以用来解决供体器官短缺的问题，而且还可以作为未来再生器官替代疗法的基础。
A three-dimensional multicellular organism maintains the biological functions of life support by using the blood circulation to transport oxygen and nutrients and to regulate body temperature for intracellular enzymatic reactions. Donor organ transplantation using low-temperature storage is used as the fundamental treatment for dysfunctional organs. However, this approach has a serious problem in that donor organs maintain healthy conditions only during short-term storage. In this study, we developed a novel liver perfusion culture system based on biological metabolism that can maintain physiological functions, including albumin synthesis, bile secretion and urea production. This system also allows for the resurrection of a severely ischaemic liver. This study represents a significant advance for the development of an ex vivo organ perfusion system based on biological metabolism. It can be used not only to address donor organ shortages but also as the basis of future regenerative organ replacement therapy.
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DOI：
10.1186/2047-1440-2-19
发表时间：
2013-11-27
期刊：
Transplantation research
影响因子：
--
作者：
Matsuno N;Kobayashi E
通讯作者：
Kobayashi E
影响因子：
56.9
作者：
Blackstone, E;Morrison, M;Roth, MB
通讯作者：
Roth, MB
影响因子：
6.5
作者：
MESCON, H;HURLEY, HJ;MORETTI, G
通讯作者：
MORETTI, G
影响因子：
9
作者：
Hata, Toshiyuki;Uemoto, Shinji;Kobayashi, Eiji
通讯作者：
Kobayashi, Eiji
DOI：
10.1007/bf00692726
发表时间：
1988-01-01
影响因子：
2
作者：
GEISER, F
通讯作者：
GEISER, F