Postprandial Blood Glucose Outweighs Fasting Blood Glucose and HbA1c in screening Coronary Heart Disease.
Postprandial Blood Glucose Outweighs Fasting Blood Glucose and HbA1c in screening Coronary Heart Disease.
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餐后血糖优于空腹血糖和 HbA1c 来筛查冠心病
DOI：
10.1038/s41598-017-14152-y
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发表时间：
2017-10-27
影响因子：
4.6
通讯作者：
Gao X
中科院分区：
文献类型：
--
作者：
Jiang J;Zhao L;Lin L;Gui M;Aleteng Q;Wu B;Wang S;Pan B;Ling Y;Gao X
本研究的目的是评估空腹血糖（FBG）、餐后血糖（PBG）和糖化血红蛋白（HbA 1c）在接受冠状动脉造影的住院人群中筛查冠心病（CHD）的性能。根据FBG、PBG和HbA 1c，将1852例计划进行冠状动脉造影的连续患者分为正常葡萄糖耐量（NGT）、葡萄糖调节受损（IGR）和糖尿病。分析Gensini评分与糖代谢、胰岛素抵抗的相关性。分别采用多元线性回归和Logistic回归分析血糖变量与Gensini评分和冠心病的关系。NGT、IGR和糖尿病患者分别有488、622和414例被诊断为CHD。Gensini评分与FBG（r = 0.09，p < 0.01）、PBG（r = 0.20，p < 0.01）和HbA 1c（r = 0.19，p < 0.01）呈正相关。Gensini评分与空腹胰岛素（r =-0.081，p = 0.36）、餐后胰岛素（r =-0.02，p = 0.61）或HOMAIR（r =-0.0059，p = 0.13）无关。当FBG、PBG和HbA 1c合并时，只有PBG与Gensini评分和CHD患病率保持相关性。在中国人群中，CHD的严重程度与葡萄糖而不是胰岛素抵抗相关。PBG与CHD的存在和严重程度最佳相关。
The objective of the present study is to assess the performance of fasting blood glucose (FBG), postprandial blood glucose (PBG), and glycated hemoglobin (HbA1c) as screening for coronary heart disease (CHD) in an inpatient population undergoing coronary angiography. 1852 consecutive patients scheduled for coronary angiography were classified into Normal Glucose Tolerance (NGT), Impaired Glucose Regulation (IGR), and diabetes, based on FBG, PBG, and HbA1c. Correlations of Gensini score with glucose metabolism and insulin resistance were analyzed. The associations between glycemic variables and Gensini score or the presence of CHD were analyzed by multiple linear regression and logistic regression, respectively. CHD was diagnosed in 488, 622, and 414 patients with NGT, IGR, and diabetes, respectively. Gensini score was positively correlated with FBG (r = 0.09, p < 0.01), PBG (r = 0.20, p < 0.01), and HbA1c (r = 0.19, p < 0.01). Gensini score was not correlated with fasting insulin (r = −0.081, p = 0.36), post-prandial insulin (r = −0.02, p = 0.61), or HOMAIR (r = −0.0059, p = 0.13). When FBG, PBG and HbA1c were pooled altogether, only PBG persisted in its association with Gensini score and the prevalence of CHD. The severity of CHD was associated with glucose rather than insulin resistance in this Chinese population. PBG was optimally correlated with the presence and severity of CHD.
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影响因子：
16.2
作者：
Bonora E;Tuomilehto J
通讯作者：
Tuomilehto J
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影响因子：
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作者：
Ding Y;Sun X;Shan PF
通讯作者：
Shan PF
影响因子：
16.2
作者：
Fox, CS;Sullivan, L;Wilson, PWF
通讯作者：
Wilson, PWF
影响因子：
37.8
作者：
Davis, Timothy M. E.;Coleman, Ruth L.;Holman, Rury R.
通讯作者：
Holman, Rury R.
影响因子：
16.2
作者：
Kataoka, Y;Yasuda, S;Miyazaki, S
通讯作者：
Miyazaki, S