Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches.
Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches.
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DOI：
10.1038/ncomms1784
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发表时间：
2012-04-17
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
器官替代再生疗法据称能够在可预见的未来替换因疾病、损伤或衰老而受损的器官。在此，我们通过皮内移植生物工程化的被毛和触须毛囊胚，展示了完全功能性的毛发器官再生。被毛和触须分别由胚胎皮肤来源的细胞和成年触须干细胞区域来源的细胞重构而成。生物工程化的毛囊发育出正确的结构，并与周围的宿主组织（如表皮、立毛肌和神经纤维）形成适当的连接。生物工程化的毛囊还通过毛囊干细胞及其微环境的重新排列，显示出恢复的毛发周期和立毛现象。因此，这项研究揭示了成年组织来源的毛囊干细胞作为生物工程器官替代疗法的潜在应用。
生物工程化的毛囊可由胚胎毛囊胚细胞产生，但这些毛囊是否能与周围组织相互作用并正常发挥功能尚不清楚。在此，移植到小鼠真皮中的生物工程化毛囊与周围组织建立连接，并显示出正常的毛发周期。
Organ replacement regenerative therapy is purported to enable the replacement of organs damaged by disease, injury or aging in the foreseeable future. Here we demonstrate fully functional hair organ regeneration via the intracutaneous transplantation of a bioengineered pelage and vibrissa follicle germ. The pelage and vibrissae are reconstituted with embryonic skin-derived cells and adult vibrissa stem cell region-derived cells, respectively. The bioengineered hair follicle develops the correct structures and forms proper connections with surrounding host tissues such as the epidermis, arrector pili muscle and nerve fibres. The bioengineered follicles also show restored hair cycles and piloerection through the rearrangement of follicular stem cells and their niches. This study thus reveals the potential applications of adult tissue-derived follicular stem cells as a bioengineered organ replacement therapy. Bioengineered hair follicles can be produced from embryonic follicle germ cells, but whether these follicles can interact with the surrounding tissue and function normally is unknown. Here, bioengineered hair follicles transplanted into mouse dermis make connections with the surrounding tissue and show normal hair cycles.
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影响因子：
64.5
作者：
Fujiwara H;Ferreira M;Donati G;Marciano DK;Linton JM;Sato Y;Hartner A;Sekiguchi K;Reichardt LF;Watt FM
通讯作者：
Watt FM
影响因子：
3.4
作者：
Bianchini, Chiara;Pelucchi, Stefano;Pastore, Antonio
通讯作者：
Pastore, Antonio
影响因子：
3.5
作者：
Irie, T;Cheng, J;Saku, T
通讯作者：
Saku, T
影响因子：
11.4
作者：
HARDY, MH
通讯作者：
HARDY, MH
DOI：
10.1073/pnas.0902944106
发表时间：
2009-08-11
影响因子：
11.1
作者：
Ikeda, Etsuko;Morita, Ritsuko;Tsuji, Takashi
通讯作者：
Tsuji, Takashi