A hypothesis regarding the molecular mechanism underlying dietary soy-induced effects on seizure propensity.
A hypothesis regarding the molecular mechanism underlying dietary soy-induced effects on seizure propensity.
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DOI：
10.3389/fneur.2014.00169
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发表时间：
2014
影响因子：
3.4
通讯作者：
Westmark CJ
中科院分区：
文献类型：
--
作者：
Westmark CJ
许多神经系统疾病，包括脆性X综合征、唐氏综合症、自闭症和阿尔茨海默病，都是癫痫的共病。我们在这些依赖饮食的疾病的小鼠模型中观察到癫痫倾向的增加。具体地说，以大豆为基础的饮食加剧了幼鼠的听源性癫痫发作。通过对病历数据的回顾分析，我们还发现了食用大豆婴儿配方奶粉与自闭症儿童的癫痫发病率、癫痫共病和自闭症诊断分数之间的潜在关联。总而言之，这些数据表明，在出生后发育期间摄入高水平的大豆蛋白可能会影响神经元的兴奋性。在此，我们提出了我们关于大豆诱导癫痫倾向的分子机制的理论。我们假设，大豆植物雌激素通过雌激素受体依赖的机制干扰代谢性谷氨酸受体信号，导致关键突触蛋白的产生增加，癫痫阈值降低。
Numerous neurological disorders including fragile X syndrome, Down syndrome, autism, and Alzheimer’s disease are co-morbid with epilepsy. We have observed elevated seizure propensity in mouse models of these disorders dependent on diet. Specifically, soy-based diets exacerbate audiogenic-induced seizures in juvenile mice. We have also found potential associations between the consumption of soy-based infant formula and seizure incidence, epilepsy comorbidity, and autism diagnostic scores in autistic children by retrospective analyses of medical record data. In total, these data suggest that consumption of high levels of soy protein during postnatal development may affect neuronal excitability. Herein, we present our theory regarding the molecular mechanism underlying soy-induced effects on seizure propensity. We hypothesize that soy phytoestrogens interfere with metabotropic glutamate receptor signaling through an estrogen receptor-dependent mechanism, which results in elevated production of key synaptic proteins and decreased seizure threshold.
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影响因子：
5.3
作者：
Chonchaiya W;Au J;Schneider A;Hessl D;Harris SW;Laird M;Mu Y;Tassone F;Nguyen DV;Hagerman RJ
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