AHR Regulates NK Cell Migration via ASB2-Mediated Ubiquitination of Filamin A.
AHR Regulates NK Cell Migration via ASB2-Mediated Ubiquitination of Filamin A.
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AHR通过ASB2介导的细丝蛋白A泛素化调节NK细胞迁移
DOI：
10.3389/fimmu.2021.624284
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发表时间：
2021
影响因子：
7.3
通讯作者：
Sunwoo JB
中科院分区：
文献类型：
--
作者：
Shin JH;Moreno-Nieves UY;Zhang LH;Chen C;Dixon AL;Linde MH;Mace EM;Sunwoo JB
Natural killer (NK) cells are effector cells of the innate immune system involved in defense against virus-infected and transformed cells. The effector function of NK cells is linked to their ability to migrate to sites of inflammation or damage. Therefore, understanding the factors regulating NK cell migration is of substantial interest. Here, we show that in the absence of aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, NK cells have reduced capacity to migrate and infiltrate tumors in vivo. Analysis of differentially expressed genes revealed that ankyrin repeat and SOCS Box containing 2 (Asb2) expression was dramatically decreased in Ahr –/– NK cells and that AhR ligands modulated its expression. Further, AhR directly regulated the promoter region of the Asb2 gene. Similar to what was observed with murine Ahr –/– NK cells, ASB2 knockdown inhibited the migration of human NK cells. Activation of AHR by its agonist FICZ induced ASB2-dependent filamin A degradation in NK cells; conversely, knockdown of endogenous ASB2 inhibited filamin A degradation. Reduction of filamin A increased the migration of primary NK cells and restored the invasion capacity of AHR-deficient NK cells. Our study introduces AHR as a new regulator of NK cell migration, through an AHR-ASB2-filamin A axis and provides insight into a potential therapeutic target for NK cell-based immunotherapies.
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影响因子：
3.7
作者：
Lamsoul, Isabelle;Erard, Monique;Lutz, Pierre G.
通讯作者：
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影响因子：
4.8
作者：
Razinia, Ziba;Baldassarre, Massimiliano;Calderwood, David A.
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Calderwood, David A.
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影响因子：
16.8
作者：
Kim CH;Hashimoto-Hill S;Kim M
通讯作者：
Kim M
影响因子：
78.5
作者：
Murray, Iain A.;Patterson, Andrew D.;Perdew, Gary H.
通讯作者：
Perdew, Gary H.
NK 细胞中 T-bet 依赖性 S1P5 表达促进淋巴结和骨髓的流出。
DOI：
10.1084/jem.20090525
发表时间：
2009-10-26
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Jenne CN;Enders A;Rivera R;Watson SR;Bankovich AJ;Pereira JP;Xu Y;Roots CM;Beilke JN;Banerjee A;Reiner SL;Miller SA;Weinmann AS;Goodnow CC;Lanier LL;Cyster JG;Chun J
通讯作者：
Chun J