A New Perspective on Regulation of Pituitary Plasticity: The Network of SOX2-Positive Cells May Coordinate Responses to Challenge.
A New Perspective on Regulation of Pituitary Plasticity: The Network of SOX2-Positive Cells May Coordinate Responses to Challenge.
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DOI：
10.1210/endocr/bqac089
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发表时间：
2022-08-01
期刊：
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
每个垂体前内分泌轴都需要功能的可塑性，以支持生理状态和环境挑战对激素需求的改变。这种可塑性是在垂体水平上通过功能性细胞数量的变化来调节的，这种变化是由反应细胞的比例、每个细胞分泌的激素的数量以及内分泌细胞群中的细胞总数的变化共同引起的。功能细胞群也取决于其组织结构和功能网络。腺体输出改变的机制取决于刺激的强度，并且是轴相关的，但在所有情况下都依赖于对功能性细胞质量输出的感知及其调节。在这里，我们提出的证据表明垂体细胞群的大小受到限制，并提出这是由群体感应的一种形式介导的。我们提出垂体细胞群体感应是由内分泌细胞网络和激素阴性SOX2阳性（SOX2+ve）细胞之间的相互作用介导的，并推测后者既是细胞数量的哨兵又是执行器。SOX2+ve细胞网络直接调节多种内分泌细胞网络分泌的证据表明，它还调节内分泌细胞功能团的其他方面。SOX2+ve细胞的决策作用将允许垂体轴的精确协调，这对于它们对生理状态和挑战的适当反应以及轴修饰的优先级至关重要。
Plasticity of function is required for each of the anterior pituitary endocrine axes to support alterations in the demand for hormone with physiological status and in response to environmental challenge. This plasticity is mediated at the pituitary level by a change in functional cell mass resulting from a combination of alteration in the proportion of responding cells, the amount of hormone secreted from each cell, and the total number of cells within an endocrine cell population. The functional cell mass also depends on its organization into structural and functional networks. The mechanisms underlying alteration in gland output depend on the strength of the stimulus and are axis dependent but in all cases rely on sensing of output of the functional cell mass and its regulation. Here, we present evidence that the size of pituitary cell populations is constrained and suggest this is mediated by a form of quorum sensing. We propose that pituitary cell quorum sensing is mediated by interactions between the networks of endocrine cells and hormone-negative SOX2-positive (SOX2+ve) cells and speculate that the latter act as both a sentinel and actuator of cell number. Evidence for a role of the network of SOX2+ve cells in directly regulating secretion from multiple endocrine cell networks suggests that it also regulates other aspects of the endocrine cell functional mass. A decision-making role of SOX2+ve cells would allow precise coordination of pituitary axes, essential for their appropriate response to physiological status and challenge, as well as prioritization of axis modification.
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影响因子：
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