Functional bias of positively selected genes in Streptococcus genomes.
Functional bias of positively selected genes in Streptococcus genomes.
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DOI：
10.1016/j.meegid.2011.11.004
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Stanhope MJ
中科院分区：
文献类型：
--
作者：
Suzuki H;Stanhope MJ
非同义替换率（dN）显著高于同义替换率（dS）已被用作有利点突变固定的正选择的证据。研究表明，正选择有助于细菌病原体中毒力因子和某些功能类别的进化。链球菌属包含许多重要的人类和农业病原体。在这里，我们评估了13种链球菌的正选择，以及它们与毒力因子和功能类别的关系。我们发现，已知的毒力基因受到积极的选择压力一样多的其他基因。在多重比较的错误发现率校正后，相对于其他基因，在阳性选择的基因中没有功能类别显著过度或代表不足。我们的研究结果表明，链球菌属内的正选择的基础上dN/dS的比率是不分布的偏见，在整个生物功能。
Rates of nonsynonymous substitution (dN) significantly higher than rates of synonymous substitution (dS) have been used as evidence of positive selection for the fixation of advantageous point mutations. It has been suggested that positive selection contributes to the evolution of virulence factors and certain functional categories in bacterial pathogens. The genus Streptococcus contains a number of important human and agricultural pathogens. Here we assessed positive selection across 13 Streptococcus species, and their relationship with virulence factors and functional categories. We found that known virulence genes were subject to positive selection pressure as much as other genes. After false discovery rate correction for multiple comparisons, no functional categories were significantly over- or underrepresented in positively selected genes relative to other genes. Our results suggest that within the genus Streptococcus positive selection based on dN/dS ratios is not distributed with bias across biological functions.
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