The comprehensive microbial resource.

The comprehensive microbial resource.
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DOI:
10.1093/nar/gkp912
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发表时间:
2010-01
影响因子:
14.9
通讯作者:
Sutton G
Sutton G
中科院分区:
生物学2区
文献类型:
--
作者:
Davidsen T;Beck E;Ganapathy A;Montgomery R;Zafar N;Yang Q;Madupu R;Goetz P;Galinsky K;White O;Sutton G

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综合微生物资源或CMR(http:cmr.jcvi.org)提供了一个基于网络的中央资源,用于展示、搜索和分析完整和公开可用的细菌和古细菌基因组的序列和注释。除了显示来自GenBank的原始注释外,CMR还提供了所有基因组的二级自动结构和功能注释,以提供有效挖掘基因组数据所需的一致数据类型。预先计算的同源性搜索被存储以允许有意义的基因组比较。CMR为用户提供了50多种不同的工具,以利用571个现有基因组中的一个或多个基因组的序列和注释数据。在基因层面,用户可以查看基因注释和潜在证据。基因组水平信息包括全基因组图形显示、生化途径图和基因组概要数据。比较工具显示具有同源性和基因组比对工具的基因组之间的分析,并且可以搜索分配给所有基因/基因组的加入、注释和证据。CMR的数据和工具有助于基因组研究和分析,CMR被收录在200多份科学出版物中。CMR网站和CMR数据库的底层代码可免费下载,没有许可证限制。
The Comprehensive Microbial Resource or CMR (http://cmr.jcvi.org) provides a web-based central resource for the display, search and analysis of the sequence and annotation for complete and publicly available bacterial and archaeal genomes. In addition to displaying the original annotation from GenBank, the CMR makes available secondary automated structural and functional annotation across all genomes to provide consistent data types necessary for effective mining of genomic data. Precomputed homology searches are stored to allow meaningful genome comparisons. The CMR supplies users with over 50 different tools to utilize the sequence and annotation data across one or more of the 571 currently available genomes. At the gene level users can view the gene annotation and underlying evidence. Genome level information includes whole genome graphical displays, biochemical pathway maps and genome summary data. Comparative tools display analysis between genomes with homology and genome alignment tools, and searches across the accessions, annotation, and evidence assigned to all genes/genomes are available. The data and tools on the CMR aid genomic research and analysis, and the CMR is included in over 200 scientific publications. The code underlying the CMR website and the CMR database are freely available for download with no license restrictions.
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