Association between TAS2R38 gene polymorphisms and colorectal cancer risk: a case-control study in two independent populations of Caucasian origin.
Association between TAS2R38 gene polymorphisms and colorectal cancer risk: a case-control study in two independent populations of Caucasian origin.
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TAS2R38基因多态性与大肠癌风险之间的关联：在两个独立的高加索起源人群中进行的病例对照研究。
DOI：
10.1371/journal.pone.0020464
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Campa D
中科院分区：
文献类型：
--
作者：
Carrai M;Steinke V;Vodicka P;Pardini B;Rahner N;Holinski-Feder E;Morak M;Schackert HK;Görgens H;Stemmler S;Betz B;Kloor M;Engel C;Büttner R;Naccarati A;Vodickova L;Novotny J;Stein A;Hemminki K;Propping P;Försti A;Canzian F;Barale R;Campa D
舌粘膜和胃肠道的分子传感在检测摄入的有害药物和毒素中起着重要作用。因此，影响启动这些反应能力的遗传多态性可能对避免和/或消除对生物体可能的威胁的后续效率至关重要。通过味觉受体2R38 （TAS2R38）基因区域的标记方法，我们在德国人群（709例对照和602例）和捷克人群（623例对照和601例）中进行病例对照研究，研究了该基因区域的所有常见遗传变异与结直肠癌风险的关系。我们发现，在捷克或德国人群中，TAS2R38基因的个体snp与结直肠癌之间没有显着关联，在联合分析中也没有。然而，当我们分析二倍型和表型时，我们发现，与味觉者组相比，非味觉者组患结直肠癌的风险更高。这种关联在捷克人群中具有临界显著性（OR = 1.28, 95% CI 0.99-1.67； p值= 0.058），在德国人群中具有统计学显著性（OR = 1.36, 95% CI 1.06-1.75； p值= 0.016），在联合分析中具有统计学显著性（OR = 1.34, 95% CI 1.12-1.61； p值= 0.001）。总之，我们在两个不同的高加索人种中发现了人类苦味表型与结直肠癌风险之间的暗示性关联。
Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of avoiding and/or eliminating possible threats to the organism. By using a tagging approach in the region of Taste Receptor 2R38 (TAS2R38) gene, we investigated all the common genetic variation of this gene region in relation to colorectal cancer risk with a case-control study in a German population (709 controls and 602 cases) and in a Czech population (623 controls and 601 cases). We found that there were no significant associations between individual SNPs of the TAS2R38 gene and colorectal cancer in the Czech or in the German population, nor in the joint analysis. However, when we analyzed the diplotypes and the phenotypes we found that the non-taster group had an increased risk of colorectal cancer in comparison to the taster group. This association was borderline significant in the Czech population, (OR = 1.28, 95% CI 0.99–1.67; Pvalue = 0.058) and statistically significant in the German population (OR = 1.36, 95% CI 1.06–1.75; Pvalue = 0.016) and in the joint analysis (OR = 1.34, 95% CI 1.12–1.61; Pvalue = 0.001). In conclusion, we found a suggestive association between the human bitter tasting phenotype and the risk of CRC in two different populations of Caucasian origin.
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影响因子：
6.4
作者：
Mangold, E;Pagenstecher, C;Propping, P
通讯作者：
Propping, P
影响因子：
30.8
作者：
de Bakker, PIW;Yelensky, R;Altshuler, D
通讯作者：
Altshuler, D
影响因子：
5.5
作者：
Mace, Oliver J.;Lister, Norma;Foley, David
通讯作者：
Foley, David
影响因子：
3.1
作者：
Basson, MD;Bartoshuk, LM;Duffy, VB
通讯作者：
Duffy, VB
影响因子：
2.4
作者：
Campa D;Pardini B;Naccarati A;Vodickova L;Novotny J;Steinke V;Rahner N;Holinski-Feder E;Morak M;Schackert HK;Görgens H;Kötting J;Betz B;Kloor M;Engel C;Büttner R;Propping P;Försti A;Hemminki K;Barale R;Vodicka P;Canzian F
通讯作者：
Canzian F