Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand.
Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand.
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DOI：
10.3390/molecules23040813
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发表时间：
2018-04-02
期刊：
影响因子：
--
通讯作者：
Park S
中科院分区：
文献类型：
--
作者：
Azam M;Al-Resayes SI;Wabaidur SM;Altaf M;Chaurasia B;Alam M;Shukla SN;Gaur P;Albaqami NTM;Islam MS;Park S
本文报道了一种新的偶氮甲亚胺配体HL及其与Cu（II）和Fe（III）的配合物。配体及其配合物通过各种物理化学技术进行表征，包括C，H，N分析，FT-IR，1H-NMR，ESI-MS和UV-Vis研究。TGA分析表明复合物是足够稳定的，并经历两步降解过程。用循环伏安法研究了配合物的氧化还原行为。此外，通过测定抑菌圈、最小抑菌浓度（MIC）和最小杀菌浓度（MBC）来测试配体及其复合物对细菌和真菌菌株的抗微生物活性。当对革兰氏+ve和革兰氏−ve细菌菌株进行测试时，复合物显示出中等的抗微生物活性。为了深入了解配体的结构，记录了DFT研究。所得结果与实验结果相当接近。利用HOMO、LUMO能量值计算了配体的能隙、化学硬度、化学柔软度、电负性、亲电指数和化学势。
We are reporting a novel azo-azomethine ligand, HL and its complexes with Cu(II) and Fe(III) ions. The ligand and its complexes are characterized by various physico-chemical techniques using C,H,N analyses, FT-IR, 1H-NMR, ESI-MS and UV-Vis studies. TGA analyses reveal complexes are sufficiently stable and undergo two-step degradation processes. The redox behavior of the complexes was evaluated by cyclic voltammetry. Furthermore, the ligand and its complexes were tested for antimicrobial activity against bacterial and fungal strains by determining inhibition zone, minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). The complexes showed moderate antimicrobial activity when tested against Gram +ve and Gram −ve bacterial strains. To obtain insights into the structure of ligand, DFT studies are recorded. The results obtained are quite close to the experimental results. In addition, the energy gap, chemical hardness, softness, electronegativity, electrophilic index and chemical potential were calculated using HOMO, LUMO energy value of ligand.
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DOI：
10.1111/febs.14315
发表时间：
2018-01
期刊：
The FEBS journal
影响因子：
--
作者：
Lewandowski EM;Lethbridge KG;Sanishvili R;Skiba J;Kowalski K;Chen Y
通讯作者：
Chen Y
影响因子：
3.1
作者：
Alam, Mahboob;Alam, Mohammad Jane;Ahmad, Shabbir
通讯作者：
Ahmad, Shabbir
影响因子：
4.4
作者：
FUKUI, K;YONEZAWA, T;SHINGU, H
通讯作者：
SHINGU, H
影响因子：
3.1
作者：
Aqil, F;Khan, MSA;Ahmad, I
通讯作者：
Ahmad, I
影响因子：
2.8
作者：
Lewandowski EM;Szczupak Ł;Wong S;Skiba J;Guśpiel A;Solecka J;Vrček V;Kowalski K;Chen Y
通讯作者：
Chen Y