Additive cortical gray matter deficits in people living with HIV who use cocaine.
Additive cortical gray matter deficits in people living with HIV who use cocaine.
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DOI：
10.1007/s13365-023-01111-9
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发表时间：
2023-02
影响因子：
3.2
通讯作者：
Meade, Christina S.
中科院分区：
文献类型：
--
作者：
Bell, Ryan P.;Towe, Sheri L.;Al-Khalil, Kareem;Gibson, Matthew;Nadeem, Tauseef;Meade, Christina S.
可卡因的使用在艾滋病毒感染者（PWH）中不成比例地常见，已知其具有神经毒性作用，可能会加剧艾滋病毒的神经发病机制。虽然可卡因使用和艾滋病毒疾病都与灰质（GM）体积的缺陷独立相关，但可卡因使用对艾滋病毒疾病对GM体积的累加效应尚未探讨。在这里，我们调查了四组有和没有HIV疾病和/或可卡因使用的个体之间的皮质下和皮质脑容量差异。参与者还完成了一项全面的神经心理学测试，并记录了艾滋病毒疾病的特征。在皮质下区域，可卡因的使用与背侧纹状体和苍白球的体积增加独立相关，而HIV疾病与丘脑和丘脑的体积减少相关。对于皮质区域，可卡因使用对HIV疾病的顶叶和枕叶体积存在叠加效应，使用可卡因的PWH显示出最低的GM体积。在组间不同的区域内，较高的神经认知功能与丘脑、丘脑核、背侧纹状体和枕叶体积呈正相关。对于显示出HIV疾病的显著主要影响的区域，较低的最低CD 4 + T细胞计数与较低的丘脑核和枕叶体积相关。较低的当前CD 4 + T细胞计数与较低的枕叶体积相关。这些结果表明，使用可卡因的PWH比单独使用可卡因或HIV疾病更容易发生皮质萎缩。
Cocaine use, which is disproportionately common in people living with HIV (PWH), is known to have neurotoxic effects that may exacerbate HIV neuropathogenesis. While both cocaine use and HIV disease are independently associated with deficits in gray matter (GM) volume, the additive effect of cocaine use to HIV disease on GM volume has not been explored. Here, we investigated subcortical and cortical brain volume differences between four groups of individuals with and without HIV disease and/or cocaine use. Participants also completed a comprehensive neuropsychological testing battery, and HIV disease characteristics were recorded. Within subcortical regions, cocaine use was independently associated with higher volume in the dorsal striatum and pallidum, while HIV disease was associated with lower volume in the nucleus accumbens and thalamus. For cortical regions, there was an additive effect of cocaine use on HIV disease in parietal and occipital lobe volume with PWH who used cocaine displaying the lowest GM volume. Within regions that differed between groups, higher neurocognitive function was positively associated with the thalamus, nucleus accumbens, dorsal striatum, and occipital lobe volume. For regions that showed a significant main effect of HIV disease, lower nadir CD4+ T-cell count was associated with lower nucleus accumbens and occipital lobe volume. Lower current CD4+ T-cell count was associated with lower occipital lobe volume. These results suggest that PWH who use cocaine are at greater risk for cortical atrophy than cocaine use or HIV disease alone.
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影响因子：
3.8
作者：
Cook, Judith A.;Burke-Miller, Jane K.;Cohen, Mardge H.;Cook, Robert L.;Vlahov, David;Wilson, Tracey E.;Golub, Elizabeth T.;Schwartz, Rebecca M.;Howard, Andrea A.;Ponath, Claudia;Plankey, Michael W.;Levine, Andrea;Grey, Dennis D.
通讯作者：
Grey, Dennis D.
影响因子：
4.7
作者：
Bell RP;Foxe JJ;Ross LA;Garavan H
通讯作者：
Garavan H
DOI：
10.3758/s13415-020-00806-4
发表时间：
2020-08
期刊：
Cognitive, affective & behavioral neuroscience
影响因子：
--
作者：
Bell RP;Towe SL;Lalee Z;Huettel SA;Meade CS
通讯作者：
Meade CS
DOI：
10.1076/jcen.25.4.571.13876
发表时间：
2003-06-01
影响因子：
2.2
作者：
Diehr, MC;Cherner, M;Heaton, RK
通讯作者：
Heaton, RK
DOI：
10.1016/j.jana.2015.12.001
发表时间：
2017-03
期刊：
The Journal of the Association of Nurses in AIDS Care : JANAC
影响因子：
--
作者：
Dawson-Rose C;Draughon JE;Zepf R;Cuca YP;Huang E;Freeborn K;Lum PJ
通讯作者：
Lum PJ