Neural sensitivity to risk in adults with co-occurring HIV infection and cocaine use disorder.
Neural sensitivity to risk in adults with co-occurring HIV infection and cocaine use disorder.
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DOI：
10.3758/s13415-020-00806-4
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发表时间：
2020-08
期刊：
影响因子：
--
通讯作者：
Meade CS
中科院分区：
文献类型：
--
作者：
Bell RP;Towe SL;Lalee Z;Huettel SA;Meade CS
同时患有艾滋病毒感染和可卡因使用障碍的人往往会做出风险更大的决策。然而，该人群中风险敏感性的神经相关性尚未得到充分表征。本研究的目的是检查艾滋病毒感染和可卡因使用障碍对风险敏感性的神经相互作用影响。样本包括 79 名成年人，他们在艾滋病毒状况和可卡因使用障碍方面存在差异。在功能磁共振成像 (fMRI) 过程中，参与者完成了财富之轮 (WoF) 任务，该任务评估神经激活对货币风险变化的反应（即赢得较大奖励的概率较低）。在各组中，皮质和皮质下区域的神经激活导致风险增加，这与之前在非吸毒人群中使用 WoF 进行的研究类似。我们的分析表明，艾滋病毒感染和可卡因使用之间在左侧楔前叶/后扣带皮层和海马，以及右侧中央后回、枕外侧皮层、小脑和后顶叶皮层中存在协同效应。患有可卡因使用障碍的 HIV+ 个体表现出神经过度活跃，导致风险增加，而其他组中未观察到这一点。这些结果支持同时发生的艾滋病毒感染和可卡因依赖在可能反映补偿的风险概率的神经处理中的协同效应。未来的研究可以进一步调查和验证增加风险的神经激活如何与冒险行为相关。这项研究尚未正式预注册。研究数据尚未提供给开源数据库。
Persons with co-occurring HIV infection and cocaine use disorder tend to engage in riskier decision-making. However, the neural correlates of sensitivity to risk are not well-characterized in this population. The purpose of this study was to examine the neural interaction effects of HIV infection and cocaine use disorder to sensitivity to risk. The sample included 79 adults who differed on HIV status and cocaine use disorder. During functional magnetic resonance imaging (fMRI), participants completed a Wheel of Fortune (WoF) task that assessed neural activation in response to variations of monetary risk (i.e., lower probability of winning a larger reward). Across groups, neural activation to increasing risk was in cortical and subcortical regions similar to previous investigations using the WoF in nondrug-using populations. Our analyses showed that there was a synergistic effect between HIV infection and cocaine use in the left precuneus/posterior cingulate cortex and hippocampus, and right postcentral gyrus, lateral occipital cortex, cerebellum, and posterior parietal cortex. HIV+ individuals with cocaine use disorder displayed neural hyperactivation to increasing risk that was not observed in the other groups. These results support a synergistic effect of co-occurring HIV infection and cocaine dependence in neural processing of risk probability that may reflect compensation. Future studies can further investigate and validate how neural activation to increasing risk is associated with risk-taking behavior. This study was not formally preregistered. Study data have not yet been provided to open source databases.
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DOI：
10.1080/13854046.2012.740077
发表时间：
2013
期刊：
The Clinical neuropsychologist
影响因子：
--
作者：
Iudicello JE;Woods SP;Cattie JE;Doyle K;Grant I;HIV Neurobehavioral Research Program Group
通讯作者：
HIV Neurobehavioral Research Program Group
影响因子：
3.7
作者：
Connolly CG;Bischoff-Grethe A;Jordan SJ;Woods SP;Ellis RJ;Paulus MP;Grant I;Translational Methamphetamine AIDS Research Center (TMARC) Group
通讯作者：
Translational Methamphetamine AIDS Research Center (TMARC) Group
HIV 功能 MRI 综述：衰老和药物治疗的影响。
影响因子：
3.2
作者：
Hakkers CS;Arends JE;Barth RE;Du Plessis S;Hoepelman AI;Vink M
通讯作者：
Vink M
影响因子：
4.4
作者：
Heil, Sarah H.;Johnson, Matthew W.;Bickel, Warren K.
通讯作者：
Bickel, Warren K.
影响因子：
4.5
作者：
Cheng, Tessa;Johnston, Caitlin;DeBeck, Kora
通讯作者：
DeBeck, Kora