CD38 expression levels in chronic lymphocytic leukemia B cells are associated with activation marker expression and differential responses to interferon stimulation.
CD38 expression levels in chronic lymphocytic leukemia B cells are associated with activation marker expression and differential responses to interferon stimulation.
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慢性淋巴细胞白血病 B 细胞中的 CD38 表达水平与激活标记物表达和对干扰素刺激的差异反应相关。
DOI：
10.1038/sj.leu.2403975
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发表时间：
2005
期刊：
影响因子：
11.4
通讯作者：
Jelinek,DF
中科院分区：
文献类型：
--
作者：
Pittner,BT;Shanafelt,TD;Kay,NE;Jelinek,DF
CD38, a surface protein whose expression increases upon normal B-cell activation, is a marker of disease aggression in B-cell chronic lymphocytic leukemia (B-CLL). Higher percentages of CD38-expressing CLL B cells may be found in lymphoid compartments compared to peripheral blood. Therefore, it is possible that although CLL B cells are resting, CD38 may be a marker of recent cell activation prior to entry into the periphery. To address this hypothesis, we examined the association of CD38 expression with other activation antigens identified in gene expression profiling experiments and include CD18, CD49d, CD20, and subunit 5 of the anaphase-promoting complex/cyclosome. We found that all these markers were more highly expressed in leukemic B cells from CD38-positive CLL patients. Lastly, because interferon is known to modulate CD38 expression, we used IFN-α to test the ability of CLL B cells to increase CD38 expression in vitro. Interestingly, IFN stimulation only modulated CD38 expression in CLL B cells that already expressed CD38. Taken together, these data suggest that CD38 is a marker of a more recently activated CLL B cell. This in turn may explain the biological and clinical differences between CD38-positive type B-CLL and CD38-negative type B-CLL.
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语言、记忆和衰老：主题索引
影响因子：
2.7
作者：
L. Light;D. Burke
通讯作者：
D. Burke
通过识别和阅读时间来评估正常人和记忆受损的阿尔茨海默病和其他神经系统疾病患者的记忆力。
DOI：
10.1037//0096-3445.115.4.331
发表时间：
1986
期刊：
Journal of experimental psychology. General
影响因子：
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作者：
Morris Moscovitch;G. Winocur;Don McLachlan
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DOI：
10.1037/0278-7393.13.3.474
发表时间：
1987-07-01
影响因子：
2.6
作者：
CRAIK, FIM;MCDOWD, JM
通讯作者：
MCDOWD, JM
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DOI：
10.1007/978-1-4612-3852-2_1
发表时间：
1988
期刊：
The International journal of neuroscience
影响因子：
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作者：
D. Howard
通讯作者：
D. Howard
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DOI：
--
发表时间：
1988
期刊：
影响因子：
--
作者：
L. Light;D. Burke
通讯作者：
D. Burke