Spatially resolved transcriptomics and its applications in cancer.

Spatially resolved transcriptomics and its applications in cancer.
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空间分辨转录组学及其在癌症中的应用。

DOI:
10.1016/j.gde.2020.12.002
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发表时间:
2021-03
影响因子:
4
通讯作者:
Phatnani H
Phatnani H
中科院分区:
生物学2区
文献类型:
--
作者:
Maniatis S;Petrescu J;Phatnani H

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空间分辨转录组学(SRT)提供了在完整组织的背景下理解细胞及其功能障碍模式的希望。近年来,SRT技术发展迅速,发表了大量研究成果。各种不同的SRT方法产生的数据在深度、吞吐量、可访问性和成本方面差异很大。许多已发表的SRT方法仅在其原始实验室中得到证明,而其他方法已经成熟到商业化和广泛可用的程度。本文就SRT技术及其在肿瘤异质性研究中的应用作一综述。
Spatially resolved transcriptomics (SRT) offers the promise of understanding cells and their modes of dysfunction in the context of intact tissues. Technologies for SRT have advanced rapidly with a large number being published in recent years. Diverse methods for SRT produce data at widely varying depth, throughput, accessibility and cost. Many published SRT methods have been demonstrated only in their labs of origin, while others have matured to the point of commercialization and widespread availability. Here we review technologies for SRT, and their application in studies of tumor heterogeneity.
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