Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair Cells.
Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair Cells.
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DOI：
10.3389/fncel.2018.00252
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发表时间：
2018
影响因子：
5.3
通讯作者：
Duncan JS
中科院分区：
文献类型：
--
作者：
Elliott KL;Fritzsch B;Duncan JS
本文综述了Corti器毛细胞的进化和发育，重点介绍了其与前庭毛细胞的分子差异。需要这些信息来治疗性地指导扁平上皮中的Corti毛细胞器官发育，并产生不同毛细胞类型的正确排列、静纤毛的定向和动纤毛的延迟丧失，这些都是听力所必需的，同时避免将毛细胞推向前庭命运。强调前庭器官的差异，并定义已知的这些差异的调节将有助于集中未来的研究方向，对长期毛细胞损失后的Corti器官的成功恢复。
We review the evolution and development of organ of Corti hair cells with a focus on their molecular differences from vestibular hair cells. Such information is needed to therapeutically guide organ of Corti hair cell development in flat epithelia and generate the correct arrangement of different hair cell types, orientation of stereocilia, and the delayed loss of the kinocilium that are all essential for hearing, while avoiding driving hair cells toward a vestibular fate. Highlighting the differences from vestibular organs and defining what is known about the regulation of these differences will help focus future research directions toward successful restoration of an organ of Corti following long-term hair cell loss.
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影响因子：
7.7
作者：
Bucks, Stephanie A.;Cox, Brandon C.;Stone, Jennifer S.
通讯作者：
Stone, Jennifer S.
影响因子：
16.6
作者：
Giese APJ;Tang YQ;Sinha GP;Bowl MR;Goldring AC;Parker A;Freeman MJ;Brown SDM;Riazuddin S;Fettiplace R;Schafer WR;Frolenkov GI;Ahmed ZM
通讯作者：
Ahmed ZM
影响因子：
3.7
作者：
Booth KT;Azaiez H;Jahan I;Smith RJH;Fritzsch B
通讯作者：
Fritzsch B
DOI：
10.1073/pnas.1222341110
发表时间：
2013-08-20
影响因子：
11.1
作者：
Bok, Jinwoong;Zenczak, Colleen;Wu, Doris K.
通讯作者：
Wu, Doris K.
影响因子：
2.4
作者：
Basch ML;Brown RM 2nd;Jen HI;Groves AK
通讯作者：
Groves AK