A biphasic finite element study on the role of the articular cartilage superficial zone in confined compression.
A biphasic finite element study on the role of the articular cartilage superficial zone in confined compression.
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DOI：
10.1016/j.jbiomech.2014.11.007
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发表时间：
2015-01-02
影响因子：
2.4
通讯作者：
Torzilli, Peter A.
中科院分区：
文献类型：
--
作者：
Guo, Hongqiang;Maher, Suzanne A.;Torzilli, Peter A.
本研究的目的是探讨关节软骨表浅区对关节软骨力学行为的影响。使用双相有限元分析对关节软骨的受限压缩进行建模，以计算细胞外基质（ECM）的一维变形和间质液通过ECM和关节表面的运动。关节软骨被建模为一个不均匀的，非线性超弹性双相材料与深度和应变依赖的材料特性。模拟了两种加载条件，一种是用多孔压板加载浅表区（正常测试），另一种是用多孔压板加载深部区（倒置测试）。用0.2MPa的应力压缩完整的关节软骨使表面渗透性降低了88%。去除浅表区增加了所有机械参数的变化率，降低了组织的液体支持率，导致组织变形增加。在正常测试中，表观渗透率在表面去除后线性增加，但在倒置测试中没有变化。标本的方向影响关节软骨的时间依赖性生物力学行为，但不影响平衡行为。不同试样方向的两个试验导致非常不同的表观渗透率，这表明在量化非均匀材料的材料特性的实验研究中，试样方向应与渗透率结果一起沿着说明。目前的研究提供了新的见解浅区的关节软骨的力学行为的作用。
The aim of this study was to investigate the role of the superficial zone on the mechanical behavior of articular cartilage. Confined compression of articular cartilage was modeled using a biphasic finite element analysis to calculate the one-dimensional deformation of the extracellular matrix (ECM) and movement of the interstitial fluid through the ECM and articular surface. The articular cartilage was modeled as an inhomogeneous, nonlinear hyperelastic biphasic material with depth and strain-dependent material properties. Two loading conditions were simulated, one where the superficial zone was loaded with a porous platen (normal test) and the other where the deep zone was loaded with the porous platen (upside down test). Compressing the intact articular cartilage with 0.2 MPa stress reduced the surface permeability by 88%. Removing the superficial zone increased the rate of change for all mechanical parameters and decreased the fluid support ratio of the tissue, resulting in increased tissue deformation. Apparent permeability linearly increased after superficial removal in the normal test, yet it did not change in the upside down test. Orientation of the specimen affected the time-dependent biomechanical behavior of the articular cartilage, but not equilibrium behavior. The two tests with different specimen orientations resulted in very different apparent permeabilities, suggesting that in an experimental study which quantifies material properties of an inhomogeneous material, the specimen orientation should be stated along with the permeability result. The current study provides new insights into the role of the superficial zone on mechanical behavior of the articular cartilage.
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影响因子：
2.8
作者：
Gratz, Kenneth R.;Wong, Benjamin L.;Bae, Won C.;Sah, Robert L.
通讯作者：
Sah, Robert L.
影响因子：
2.8
作者：
Schinagl, RM;Gurskis, D;Sah, RL
通讯作者：
Sah, RL
DOI：
10.1177/0954411914522782
发表时间：
2014-03-01
影响因子：
1.8
作者：
Guo, Hongqiang;Shah, Mitul;Spilker, Robert L.
通讯作者：
Spilker, Robert L.
DOI：
10.2106/00004623-198062070-00007
发表时间：
1980-01-01
影响因子：
5.3
作者：
ROTH, V;MOW, VC
通讯作者：
MOW, VC
影响因子：
2.4
作者：
Chen, AC;Bae, WC;Sah, RL
通讯作者：
Sah, RL