Toxoplasma gondii's Basal Complex: The Other Apicomplexan Business End Is Multifunctional.
Toxoplasma gondii's Basal Complex: The Other Apicomplexan Business End Is Multifunctional.
复制标题
DOI：
10.3389/fcimb.2022.882166
复制
发表时间：
2022
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
顶复门以其顶端复合体而闻名，顶端复合体是一组细胞器，专门用于入侵宿主细胞。相比之下，在细胞的另一端，基底复合体（BC）被掩盖了，因为它不那么突出，具体功能也不明显。然而，在过去十年中，与业务连续性有关的职能数量惊人，在了解其结构方面也取得了很大进展。在这里，这些集体的见解补充了新的数据，以提供一个概述的了解弓形虫的BC。出现的画面是，BC是一个动态的和多功能的复杂，与一系列（假定）的功能。BC在细胞分裂中具有多种作用：它是将构建块添加到细胞骨架支架的位点;它作为收缩环发挥两步拉伸和收缩机制;并且它是细胞器分裂的关键。此外，BC在“进口”中具有许多假定的作用，例如母细胞残余物的回收、宿主衍生的囊泡的获得、可能的来自细胞外介质的脂质的摄取以及微线蛋白的内吞作用。后一个过程将BC与运动性联系起来，而肌球蛋白C在运动性中具有额外的作用。此外，BC作用于液泡内网络的组装和/或功能，这可能直接或间接地有助于慢性组织囊肿的建立。在这里，我们提供了实验支持分子在这些过程中发挥作用，并确定了几个新的BC蛋白质的关键，以维持分裂的寄生虫之间的细胞质桥。然而，许多BC组件的可扩展性留下了许多关于其功能的问题。最后，T.弓形虫是寄生虫后端的动态和多功能结构。
The Apicomplexa are famously named for their apical complex, a constellation of organelles at their apical end dedicated to invasion of their host cells. In contrast, at the other end of the cell, the basal complex (BC) has been overshadowed since it is much less prominent and specific functions were not immediately obvious. However, in the past decade a staggering array of functions have been associated with the BC and strides have been made in understanding its structure. Here, these collective insights are supplemented with new data to provide an overview of the understanding of the BC in Toxoplasma gondii. The emerging picture is that the BC is a dynamic and multifunctional complex, with a series of (putative) functions. The BC has multiple roles in cell division: it is the site where building blocks are added to the cytoskeleton scaffold; it exerts a two-step stretch and constriction mechanism as contractile ring; and it is key in organelle division. Furthermore, the BC has numerous putative roles in ‘import’, such as the recycling of mother cell remnants, the acquisition of host-derived vesicles, possibly the uptake of lipids derived from the extracellular medium, and the endocytosis of micronemal proteins. The latter process ties the BC to motility, whereas an additional role in motility is conferred by Myosin C. Furthermore, the BC acts on the assembly and/or function of the intravacuolar network, which may directly or indirectly contribute to the establishment of chronic tissue cysts. Here we provide experimental support for molecules acting in several of these processes and identify several new BC proteins critical to maintaining the cytoplasmic bridge between divided parasites. However, the dispensable nature of many BC components leaves many questions unanswered regarding its function. In conclusion, the BC in T. gondii is a dynamic and multifunctional structure at the posterior end of the parasite.
登录
查看更多内容
影响因子：
2.1
作者：
Ferguson, DJP;Cesbron-Delauw, MF;Wright, S
通讯作者：
Wright, S
影响因子：
6.4
作者：
Dou Z;McGovern OL;Di Cristina M;Carruthers VB
通讯作者：
Carruthers VB
影响因子：
64.5
作者：
Coppens, I;Dunn, JD;Joiner, KA
通讯作者：
Joiner, KA
影响因子：
3.4
作者：
Engelberg K;Ivey FD;Lin A;Kono M;Lorestani A;Faugno-Fusci D;Gilberger TW;White M;Gubbels MJ
通讯作者：
Gubbels MJ
影响因子：
2
作者：
DUBREMETZ, JF;ACHBAROU, A;JOINER, KA
通讯作者：
JOINER, KA